Pairwise Alignments
Query, 1431 a.a., two-component system sensor histidine kinase/response regulator, hybrid ('one-component system') (NCBI ptt file) from Bacteroides thetaiotaomicron VPI-5482
Subject, 1349 a.a., hybrid sensor histidine kinase/response regulator from Pedobacter sp. GW460-11-11-14-LB5
Score = 581 bits (1497), Expect = e-169
Identities = 389/1354 (28%), Positives = 693/1354 (51%), Gaps = 131/1354 (9%)
Query: 170 LSSDKVLFVYESNDSPGHVWIGTKQGLWKYHDGKLEAMDTQGESWEHIFSYD-------- 221
LS VL + + DS G++W GT+ L +Y ++ T ++ I + D
Sbjct: 19 LSQSTVLSICK--DSRGYMWFGTRDCLNRYDGKSVKIYRTDPDNPASISTEDYIYALEED 76
Query: 222 -QYTCIITGKKEIYRHSLSNNRLEKIA----SLTELGDTGVITGSLRLQHQWVMFTATGS 276
Q I + + R+ + E+IA + + D ++ S+ ++ T
Sbjct: 77 RQKNLWIGTQNGLNRYIPEKDAFERIAFDPKNANSISDKIIL--SIYADRSGKVWFGTNQ 134
Query: 277 YILDPVTGKLRRFSRLNIKNG-------NVTRDNKGNAWVHNYTGNVWYVNTSTGD--IK 327
+ G R+F ++ K+G + D+KGN WV TG + ++ G I+
Sbjct: 135 GLSMLENGSSRKFKKIYQKDGLAGNSVYTIFEDSKGNIWVGTTTG-LSRLSFKEGKYHIQ 193
Query: 328 HFQFLSSEHLGYIDVERYSIIHDSRDIIWITTYGNGLFAYDLNTGDLQHFTFEVSHSSHI 387
F + + +I D + IWI + GL + + + F + + +
Sbjct: 194 SFYHRAGDPGSISGNSIRTIAEDGKGRIWIGSESEGLNLFLPQSHSFKRFRYSALQPNAL 253
Query: 388 NSNYLQYIIEDRSGGIWVSSEFSGLSHLEILNKGTLRIYPNGEDASDRS----NTIRMLL 443
+++ ++ I+ D G +W+++ ++ L IL+ TL DA +R N+I+ +
Sbjct: 254 SNDIVRKIMPDGKGNLWIAT----MNGLNILDTQTLGFTSYKHDADNRKSLSDNSIKEIF 309
Query: 444 RGKNGNVYMANRMG--TLYEYDADLKNILRREKFTHNVYS-----MCEDNEGQLWLGMRG 496
+ G++++ G + + + + K+ +++ S + DN+ LW+G G
Sbjct: 310 QDDQGSIWIGTMFGGVNVAHRNTIPFTVFKYSKYRNSISSDISSVIAADNDQNLWIGTEG 369
Query: 497 IGL-----RIGADQWYRYNSKDNNSLSNDNVYLIYRDRKGRMWIGTFGGGLNLAVKTGNG 551
GL + G + Y + +D SLSN+ + I+ DRKGR+WIG + GGL L + +
Sbjct: 370 QGLNFYNVKTGLFKKYINDPRDPGSLSNNTIKAIFNDRKGRIWIGLYQGGLELFIPSTG- 428
Query: 552 YQFKHF--FQDSYGEKRVRVIQEDRNGMMWVGTNN-GIYIFHPDS--------------- 593
+FKH+ ++ + + I ED G + +GT++ G+ IF P+
Sbjct: 429 -KFKHYPPGRNGLSQGYLSSISEDDQGRLLLGTSSKGLNIFDPEKESFQLIDDQPGHGLK 487
Query: 594 -----------------LINSPK----------NYVLYNHVNET---FPSNEIRCLVNDH 623
+ +P+ ++ +++ ++T S++I CL D
Sbjct: 488 LSSSYIRFAYQDTKKNLWVGTPRGLNFLPPGANHFSVFSRDDKTKGSLKSSQITCLWEDR 547
Query: 624 EGNMWIGTTGAGFAICYPGNDYQHLTFDCYSIKDGLPNGVIQSIVEDQDNKMWIATEYGI 683
G++W+GT G ++ +P + +F Y+ GL + I +++D D +WI+T+ G+
Sbjct: 548 LGHIWVGTMRGGLSLYHPDSK----SFSTYTRAQGLASDNIIDVLDDNDGNLWISTDRGL 603
Query: 684 SRFTLATKQIENYYFSSHTLGNVYSENTACINADGRLLFGTNYGLVVLDANKVENMEKLA 743
S+F +NY N ++ N+A + G+L FG+ GLVV ++ +
Sbjct: 604 SKFDYKRGVFKNYNTGDGLPTNEFNVNSAYRDIHGKLYFGSYDGLVVFTPREITENTLIP 663
Query: 744 STVFTGLHINGAHMLPGMDDSPLNETMSYTGQLNLKHYQNSFVIAFSTFNFLSGA-SKYS 802
TVF+GL + + D+ L + +S+T + QN F + F + N++ ++Y+
Sbjct: 664 RTVFSGLKLFNKPVGINEDNGLLKQDISFTKGITFTAEQNIFSLEFVSLNYVQPQRNRYA 723
Query: 803 YRMPPYDSEWS---IPSAQNLATYRNLPPGKYQLQVKACNVAGVWGEEST-MEIVIAPPF 858
Y++ ++ +W+ IPSA +Y NLP G Y+L VK N G+W + MEI + PP
Sbjct: 724 YKLEGFEKDWNYVTIPSA----SYTNLPSGNYKLLVKGSNNDGLWSKAPVVMEIRVLPPL 779
Query: 859 WQTTWAYLIYLVFIGIVCYFSFHIIRKFNRLRNRIAVE-------KQLTEYKLEFFTNIS 911
WQT WAY +Y + G++ YF R+ +L+ + E +L + KL+FFT IS
Sbjct: 780 WQTWWAYTLYFIAGGLLLYFVLRFTRRQQKLKTELYYEHLNSERQSELYQMKLDFFTRIS 839
Query: 912 HEFRTPLTLIQGALNKLINIENPPKEMQRPLKTMDKSTQRMLRLINQLLEFRKMQKNKLA 971
HE RTPLTLI L KLI I + L+ + ++T R++RLI++LL+FRK++ L+
Sbjct: 840 HEIRTPLTLIFAPLEKLIKITAENGAVNLQLQNIKRNTDRLVRLISELLDFRKIESGNLS 899
Query: 972 LSLEETDVIAFLYEIFLSFKDTSESKNIDFSFEPSQPAYKMFIDKGNLDKVTYNLLSNAF 1031
L + E D+++F +I+ S+ +E KNID+ FE + ++ D ++KV YN+LSNAF
Sbjct: 900 LKVSENDLVSFCRQIYESYLGLAEIKNIDYRFECEAESMLVYYDPAQMEKVFYNILSNAF 959
Query: 1032 KYTPSNGKIIFKIDIQEDKQQLRIQVIDNGIGIPKEKRSELFKRFMQSSFSHSSV---GV 1088
K+TP NGKI F + ++ +I + D GIGIP + + ++F F Q ++ G+
Sbjct: 960 KFTPDNGKITFSL--KQSDGLAKIAITDTGIGIPADLQDKIFTNFFQVKNGAAATEGWGI 1017
Query: 1089 GLHLTHELVQVHKGNIS-YDE----NEGGGSVFTVLLPTNSDIYQEKDFLIPNQLLTEEE 1143
GL L ++ +HKG ++ Y E G ++ V L + + ++ + N ++T++
Sbjct: 1018 GLALAKNILDLHKGEVNVYSEPANNKRQGITILHVSLLLGKNHFSDEQ-IASNPIVTDKP 1076
Query: 1144 EQHSKDFLRNETSEDTFQPPVDPLNKRKVLIIEDDTDIREFLREEIGVYFEVEVAADGTS 1203
L +E ++ P D + VL++ED+ ++R+F+ + + + + +G
Sbjct: 1077 VAVGS--LDHELAKIQLVAPEDK-KRHTVLVVEDNDELRDFIVQSLKHTYHILEGKNGLV 1133
Query: 1204 GFEKASTYDADLIVCDVLMPGMNGFEVTRKLKNEFTTSHIPIILLTALNIEEKYQEGIES 1263
G+E A+ + D++V DV MP +NGFE+ ++LK E TT+HIP+I+LTA+ +G+E+
Sbjct: 1134 GWEVATEHVPDIVVSDVTMPELNGFELCQRLKQEETTNHIPVIMLTAMASHVHQIDGLEA 1193
Query: 1264 GADAYITKPFNVSLLLARIFKLIELRDKLRQKYSNEPGLAHSIICTNDKDQKFSVKLNEV 1323
GAD YITKPF++ +L I L++ R++LRQKY + L + T ++KF +L ++
Sbjct: 1194 GADVYITKPFSIQVLELSIRNLLQGREELRQKYIKQIMLNPRKLETASPEEKFLNRLMQL 1253
Query: 1324 LNEHMTDTDFSVNDFAGIMGLGRTVFYKKVRGVTGYSPYEYLRVMRMKKAAEMLLTEDLT 1383
+ + M D +F+V +G+ +TV YKK++ +TG S ++++ R+K+AA++L +
Sbjct: 1254 IEDGMEDPEFNVGGLVDQIGMSQTVLYKKIKALTGLSISDFIKSQRLKRAAQLLNDHKMN 1313
Query: 1384 IAEVAYSVGINDPFYFSKCFKNQFGVSPSAYRKK 1417
IAEVAYSVG ND YFSK F+ QFGV+PS Y++K
Sbjct: 1314 IAEVAYSVGFNDRKYFSKEFRKQFGVAPSEYQQK 1347
Score = 117 bits (294), Expect = 6e-30
Identities = 129/562 (22%), Positives = 228/562 (40%), Gaps = 86/562 (15%)
Query: 15 LSSVHASVEIRSNKLTTGDGLANNSIRYMFQDSKGFMWMGTVNG---LSYYDGNSFV-SI 70
LS + + K+ DGLA NS+ +F+DSKG +W+GT G LS+ +G + S
Sbjct: 136 LSMLENGSSRKFKKIYQKDGLAGNSVYTIFEDSKGNIWVGTTTGLSRLSFKEGKYHIQSF 195
Query: 71 YPDPNLPISLADPRIRNMEEDSNGFLWIATLSSLYSCYDLKHGRFVDFTGCGEYKQSYSK 130
Y P S++ IR + ED G +WI + S + + + F F + S
Sbjct: 196 YHRAGDPGSISGNSIRTIAEDGKGRIWIGSESEGLNLFLPQSHSFKRFRYSALQPNALSN 255
Query: 131 KIIA-----SDQSIWLWDNNNGCRRVVYQDGQFSSQAYKKELGN---LSSDKVLFVYESN 182
I+ ++W+ NG + Q F+S YK + N LS + + +++
Sbjct: 256 DIVRKIMPDGKGNLWI-ATMNGLNILDTQTLGFTS--YKHDADNRKSLSDNSIKEIFQ-- 310
Query: 183 DSPGHVWIGTK-QGLWKYHDGKLEAMDTQGESWEHIFSYDQYTCIITGKKEIYRHSLSNN 241
D G +WIGT G+ H + +F Y + YR+S+S++
Sbjct: 311 DDQGSIWIGTMFGGVNVAHRNTIPFT---------VFKYSK-----------YRNSISSD 350
Query: 242 RLEKIASLTELGDTGVITGSLRLQHQWVMFTATGSYILDPVTGKLRRF--------SRLN 293
IA+ + Q+ W+ G + TG +++ S N
Sbjct: 351 ISSVIAADND-------------QNLWIGTEGQGLNFYNVKTGLFKKYINDPRDPGSLSN 397
Query: 294 IKNGNVTRDNKGNAWVHNYTGNVWYVNTSTGDIKHF-QFLSSEHLGYIDVERYSIIHDSR 352
+ D KG W+ Y G + STG KH+ + GY+ SI D +
Sbjct: 398 NTIKAIFNDRKGRIWIGLYQGGLELFIPSTGKFKHYPPGRNGLSQGYLS----SISEDDQ 453
Query: 353 DIIWITTYGNGLFAYDLNTGDLQHFTFEVSHSSHINSNYLQYIIEDRSGGIWVSSEFS-- 410
+ + T GL +D Q + H ++S+Y+++ +D +WV +
Sbjct: 454 GRLLLGTSSKGLNIFDPEKESFQLIDDQPGHGLKLSSSYIRFAYQDTKKNLWVGTPRGLN 513
Query: 411 ----GLSHLEILNKGTLRIYPNGEDASDRSNTIRMLLRGKNGNVYMANRMGTLYEYDADL 466
G +H + ++ + S +S+ I L + G++++ G L Y D
Sbjct: 514 FLPPGANHFSVFSR------DDKTKGSLKSSQITCLWEDRLGHIWVGTMRGGLSLYHPDS 567
Query: 467 KNILRREK----FTHNVYSMCEDNEGQLWL----GMRGIGLRIGADQWYRYNSKDNNSLS 518
K+ + + N+ + +DN+G LW+ G+ + G + YN+ D +
Sbjct: 568 KSFSTYTRAQGLASDNIIDVLDDNDGNLWISTDRGLSKFDYKRGV--FKNYNTGDGLPTN 625
Query: 519 NDNVYLIYRDRKGRMWIGTFGG 540
NV YRD G+++ G++ G
Sbjct: 626 EFNVNSAYRDIHGKLYFGSYDG 647
Score = 109 bits (272), Expect = 2e-27
Identities = 108/473 (22%), Positives = 193/473 (40%), Gaps = 79/473 (16%)
Query: 279 LDPVTGKLRRFSRLNIKNG-------NVTRDNKGNAWVHNYTGNVWYVNTSTGDIKHFQF 331
+ PV G+L F L++ NG ++ +D++G W G +N G
Sbjct: 1 MKPVFGQLS-FDHLSVNNGLSQSTVLSICKDSRGYMWF----GTRDCLNRYDGKSVKIYR 55
Query: 332 LSSEHLGYIDVERY--SIIHDSRDIIWITTYGNGLFAYDLNTGDLQHFTFEVSHSSHINS 389
++ I E Y ++ D + +WI T NGL Y + F+ +++ I+
Sbjct: 56 TDPDNPASISTEDYIYALEEDRQKNLWIGTQ-NGLNRYIPEKDAFERIAFDPKNANSISD 114
Query: 390 NYLQYIIEDRSGGIWVSSEFSGLSHLEILNKGTLRIYPNGEDASDRSNTIRMLLRGKNGN 449
+ I DRSG +W + GLS LE NG+
Sbjct: 115 KIILSIYADRSGKVWFGTN-QGLSMLE------------------------------NGS 143
Query: 450 VYMANRMGTLYEYDADLKNILRREKFTHNVYSMCEDNEGQLWLG----MRGIGLRIGAD- 504
+ + +Y+ D N +VY++ ED++G +W+G + + + G
Sbjct: 144 ---SRKFKKIYQKDGLAGN---------SVYTIFEDSKGNIWVGTTTGLSRLSFKEGKYH 191
Query: 505 -QWYRYNSKDNNSLSNDNVYLIYRDRKGRMWIGTFGGGLNLAVKTGNG---YQFKHFFQD 560
Q + + + D S+S +++ I D KGR+WIG+ GLNL + + +++ +
Sbjct: 192 IQSFYHRAGDPGSISGNSIRTIAEDGKGRIWIGSESEGLNLFLPQSHSFKRFRYSALQPN 251
Query: 561 SYGEKRVRVIQEDRNGMMWVGTNNGIYIFHPDSLINSPKNYVLYNH---VNETFPSNEIR 617
+ VR I D G +W+ T NG+ I +L + Y H ++ N I+
Sbjct: 252 ALSNDIVRKIMPDGKGNLWIATMNGLNILDTQTL-----GFTSYKHDADNRKSLSDNSIK 306
Query: 618 CLVNDHEGNMWIGTTGAGFAICYPGNDYQHLTFDCYSIKDGLPNGVIQSIVEDQDNKMWI 677
+ D +G++WIGT G + + N F ++ + + + I D D +WI
Sbjct: 307 EIFQDDQGSIWIGTMFGGVNVAH-RNTIPFTVFKYSKYRNSISSDISSVIAADNDQNLWI 365
Query: 678 ATE-YGISRFTLATKQIENYYFSSHTLGNVYSENTACINAD--GRLLFGTNYG 727
TE G++ + + T + Y G++ + I D GR+ G G
Sbjct: 366 GTEGQGLNFYNVKTGLFKKYINDPRDPGSLSNNTIKAIFNDRKGRIWIGLYQG 418
Score = 48.1 bits (113), Expect = 6e-09
Identities = 35/143 (24%), Positives = 57/143 (39%), Gaps = 14/143 (9%)
Query: 607 VNETFPSNEIRCLVNDHEGNMWIGTTGAGFAICYPGNDYQHLTFDCYSIKDGLPNGV--- 663
VN + + + D G MW GT C N Y + Y P +
Sbjct: 15 VNNGLSQSTVLSICKDSRGYMWFGTRD-----CL--NRYDGKSVKIYRTDPDNPASISTE 67
Query: 664 --IQSIVEDQDNKMWIATEYGISRFTLATKQIENYYFSSHTLGNVYSENTACINAD--GR 719
I ++ ED+ +WI T+ G++R+ E F ++ + I AD G+
Sbjct: 68 DYIYALEEDRQKNLWIGTQNGLNRYIPEKDAFERIAFDPKNANSISDKIILSIYADRSGK 127
Query: 720 LLFGTNYGLVVLDANKVENMEKL 742
+ FGTN GL +L+ +K+
Sbjct: 128 VWFGTNQGLSMLENGSSRKFKKI 150