Pairwise Alignments
Query, 3160 a.a., type I polyketide synthase from Bifidobacterium breve UCC2003
Subject, 3069 a.a., Probable fatty acid synthase Fas (fatty acid synthetase) from Mycobacterium tuberculosis H37Rv
Score = 2581 bits (6689), Expect = 0.0
Identities = 1482/3200 (46%), Positives = 1945/3200 (60%), Gaps = 227/3200 (7%)
Query: 12 EPHALAFAGQSTPWPVTLADQTTDPSLDEDLRGHVAAANRLLAPAAADLLATTGRPVDLF 71
EP+A+AF GQ + W TL + + ++ +L V A LL P +L+ RP+
Sbjct: 32 EPYAVAFGGQGSAWLETLEELVSATGIETELATLVGEAELLLDPVTDELIVV--RPI--- 86
Query: 72 GFTPNP-ARLSAAAD----------ATASVEGVALTQLGALLDLEHLGYSVAAAKPVAVL 120
GF P R AA D A SV GV LTQ+ A L G + A PVA+
Sbjct: 87 GFEPLQWVRALAAEDPVPSDKHLTSAAVSVPGVLLTQIAATRALARQGMDLVATPPVAMA 146
Query: 121 GHSQGVLAVHMTRAIEAAGSIEAAGKTLDEILAVAALIGAAGTRRVRELGLNPKYGEASP 180
GHSQGVLAV A++A G+ + E+ A+A LIGAAGT R G++ G+ P
Sbjct: 147 GHSQGVLAVE---ALKAGGARDV------ELFALAQLIGAAGTLVARRRGISV-LGDRPP 196
Query: 181 MLSVKGATREQVEALVKR----VNNARGPISIAVTNSDNHHVLSGHPEDLAALALETERE 236
M+SV A E++ L+ V P+ +++ N V++G PE L+ L +
Sbjct: 197 MVSVTNADPERIGRLLDEFAQDVRTVLPPV-LSIRNGRRAVVITGTPEQLSRFELYCRQI 255
Query: 237 HQHQAKLREQKLHGGTVFNPTLEYLEVTLPFHSPLMAEAVEQTVSWAGACGFDQDRTRAL 296
+ + R+ K+ GG VF+P E ++V + FH+P +++ ++ WA G D R L
Sbjct: 256 SEKEEADRKNKVRGGDVFSPVFEPVQVEVGFHTPRLSDGIDIVAGWAEKAGLDVALAREL 315
Query: 297 AEEVLLNHVDWNARVKALFNAADPAKLWIVDLGPGNTLGKLIGNVVQGTGIGVVEATTLA 356
A+ +L+ VDW + + A WI+DLGPG+ L +L V++G GIG+V A T
Sbjct: 316 ADAILIRKVDWVDEITRVHAAG---ARWILDLGPGDILTRLTAPVIRGLGIGIVPAATRG 372
Query: 357 ERSALSTLESEPERTQNWKALAPRVIETPAG-AKLVTKFSKLTGKPPVLLPGMTPTTVEP 415
+ L T+ + PE + W + AP V+ P G KL TKF++LTG+ P+LL GMTPTTV+
Sbjct: 373 GQRNLFTVGATPEVARAWSSYAPTVVRLPDGRVKLSTKFTRLTGRSPILLAGMTPTTVDA 432
Query: 416 EIVAAAANAGYWAELAGGGQVTAEVFDRHIAALEDELEEGRTVEFNAMFMDRYLWNLQFG 475
+IVAAAANAG+WAELAGGGQVT E+F I + LE GRT +FNA+F+D YLW LQ G
Sbjct: 433 KIVAAAANAGHWAELAGGGQVTEEIFGNRIEQMAGLLEPGRTYQFNALFLDPYLWKLQVG 492
Query: 476 SSRIVPKKRASGAPIDGVVVSAGIPELDEAVELIKNLQADGLPYVSFKPGTVDQIRQVVR 535
R+V K R SGA IDGVV+SAGIP+LDEAVELI L G+ +V FKPGT++QIR V+R
Sbjct: 493 GKRLVQKARQSGAAIDGVVISAGIPDLDEAVELIDELGDIGISHVVFKPGTIEQIRSVIR 552
Query: 536 IAKAVAPTTIMIQVEGGEAGGHHSWEALDDLLAATYAEVRACDNLVLVAGGGIGTPERAA 595
IA V +++ VEGG AGGHHSWE LDDLL ATY+E+R+ N+ + GGGIGTP RAA
Sbjct: 553 IATEVPTKPVIMHVEGGRAGGHHSWEDLDDLLLATYSELRSRANITVCVGGGIGTPRRAA 612
Query: 596 DYISGQWAHAYGLPDMPVDGVLIGTAAMTAKEAHTSPEVKQMLVKTPGIPADAKSDDVFA 655
+Y+SG+WA AYG P MP+DG+L+GTAAM KE+ TSP VK+MLV T G
Sbjct: 613 EYLSGRWAQAYGFPLMPIDGILVGTAAMATKESTTSPSVKRMLVDTQG------------ 660
Query: 656 PQAAHWVPSGKSVGGMSSGLSHLHADIYELENDSAECGRLLVRVMKHPEELDSRRKEIIE 715
W+ +GK+ GGM+S S L ADI+E++N ++ CGRLL V E + RR EII
Sbjct: 661 --TDQWISAGKAQGGMASSRSQLGADIHEIDNSASRCGRLLDEVAGDAEAVAERRDEIIA 718
Query: 716 ALNKTAKPYFGDLASMTYLEWAQRFAELAF--------------PWADPTYADRFQHLLQ 761
A+ KTAKPYFGD+A MTYL+W +R+ ELA PW T+ DRF+ +LQ
Sbjct: 719 AMAKTAKPYFGDVADMTYLQWLRRYVELAIGEGNSTADTASVGSPWLADTWRDRFEQMLQ 778
Query: 762 RIEARANDTDSGEFTSKLFAADGVSADEAAAAGLLTRDGILADPAPALEKLALAYPQTAE 821
R EAR + D G + L T G+L +P A+ L YP
Sbjct: 779 RAEARLHPQDFGPIQT-----------------LFTDAGLLDNPQQAIAALLARYPDAET 821
Query: 822 LKVVPADVAWFPVLVREYPKPMPFVPVIDNDLLRWWGQDQLWQSEDQRYSADSVRAIPGP 881
+++ PADV +F L + KP+ FVPVID D+ RWW D LWQ+ D RY AD+V IPG
Sbjct: 822 VQLHPADVPFFVTLCKTLGKPVNFVPVIDQDVRRWWRSDSLWQAHDARYDADAVCIIPGT 881
Query: 882 ISVAGITTVDEPIADILGRFENAAIERVKAEQNASESNDFAA--LGEAVSAEDF--IRKS 937
SVAGIT +DEP+ ++L RFE AAI+ V E D A+ LG A A + +
Sbjct: 882 ASVAGITRMDEPVGELLDRFEQAAIDEVLGA--GVEPKDVASRRLGRADVAGPLAVVLDA 939
Query: 938 PNISWVGHIADNPAYGTA------LGDQYYEIRAFDAAAGKYDLDIHLDTYWDNDPDGGT 991
P++ W G NP + A + D RA ++ G L T+ D
Sbjct: 940 PDVRWAGRTVTNPVHRIADPAEWQVHDGPENPRATHSSTG-----ARLQTHGD------- 987
Query: 992 SKHAVRDIVIPLIVEGTEPGRVPVVDRERLIPDVYAMLAATAGIGNTAI--TGDKLTAMP 1049
D+ + + V GT D+ L A G T + T D +AM
Sbjct: 988 ------DVALSVPVSGT-------------WVDIRFTLPANTVDGGTPVIATEDATSAMR 1028
Query: 1050 TLSVPSDEGAVTANAVTEGETAQNRPFGTATATYTLSANLGFDHEAATGAALPSTLQPSR 1109
T+ A V E GTAT T DH T A L PS
Sbjct: 1029 TV-------LAIAAGVDSPEFLPAVANGTATLTVDWHPERVADHTGVT-ATFGEPLAPSL 1080
Query: 1110 I-APDALVGPAWPAIYTALGS-VYVKGYPVIEGLLNAVHLDHLIELEVNEEDLLKHTGET 1167
PDALVGP WPA++ A+GS V G PV+EGLL+ VHLDH + L
Sbjct: 1081 TNVPDALVGPCWPAVFAAIGSAVTDTGEPVVEGLLSLVHLDHAARV----VGQLPTVPAQ 1136
Query: 1168 ITLKSWAEDYFESASGRVVTIHVTHTAADGTLLARETERFAIRGRVYSDALPADAPEFGD 1227
+T+ + A + ++ GRVV + V T ADG ++A ERFAI GR S L AD G
Sbjct: 1137 LTVTATAANATDTDMGRVVPVSVVVTGADGAVIATLEERFAILGRTGSAEL-ADPARAGG 1195
Query: 1228 AEHAEVAPTPRRLLRRVKVVAPHDMTAFARTSGDFNPIHTSTRGARISGLAAPLVHGMWL 1287
A A TPRR R V + AP DM FA SGD NPIHT A ++GL +P+VHGMWL
Sbjct: 1196 AVSANATDTPRRRRRDVTITAPVDMRPFAVVSGDHNPIHTDRAAALLAGLESPIVHGMWL 1255
Query: 1288 SATAQHAVQALD-EKGAHYEIAGWTYNMYGMVQLDDTVEISVERVGKVRHGGMTLEVTCR 1346
SA AQHAV A D + + GWT GMV+ D V+ VERVG + G ++V R
Sbjct: 1256 SAAAQHAVTATDGQARPPARLVGWTARFLGMVRPGDEVDFRVERVG-IDQGAEIVDVAAR 1314
Query: 1347 IDGQLVSRGTALVRAPRAAFVYPGQGIQKQGMVLDERAKSAAARDVWERADKLTRAKLGF 1406
+ LV +A + AP+ + +PGQGIQ +GM ++ RA+S AAR VW+ ADK TR LGF
Sbjct: 1315 VGSDLVMSASARLAAPKTVYAFPGQGIQHKGMGMEVRARSKAARKVWDTADKFTRDTLGF 1374
Query: 1407 SILGLVRDNPKELTANGVTYRHPEGLLNLTQFTQVALATVAFAQTARLREAGADIWPAYF 1466
S+L +VRDNP + A+GV Y HP+G+L LTQFTQVA+ATVA AQ A +RE GA + A
Sbjct: 1375 SVLHVVRDNPTSIIASGVHYHHPDGVLYLTQFTQVAMATVAAAQVAEMREQGAFVEGAIA 1434
Query: 1467 AGHSLGEYNALSAFADVIPLETVLELVFHRGSTMHHLIERDAQGRSNYRMGALRPNQFGV 1526
GHS+GEY AL+ + LE +LE+VFHRGS MH ++ RD GRSNYR+ A+RP+Q +
Sbjct: 1435 CGHSVGEYTALACVTGIYQLEALLEMVFHRGSKMHDIVPRDELGRSNYRLAAIRPSQIDL 1494
Query: 1527 DDAHVKEYVESVAKASGEFLEIVNYNLAGQQYAIAGTIAGLKALKADSARRVAAFGGKPA 1586
DDA V +V +A+++GEFLEIVN+NL G QYAIAGT+ GL+AL+A+ RR GG+ +
Sbjct: 1495 DDADVPAFVAGIAESTGEFLEIVNFNLRGSQYAIAGTVRGLEALEAEVERRRELTGGRRS 1554
Query: 1587 FMLVPGIDVPFHSTLLRKGVPEFRDKLDALLPAYIDYRGRLVDRYIPNLVASPFEMTKEF 1646
F+LVPGIDVPFHS +LR GV EFR LD ++P D ++ RYIPNLV F + ++F
Sbjct: 1555 FILVPGIDVPFHSRVLRVGVAEFRRSLDRVMPRDAD-PDLIIGRYIPNLVPRLFTLDRDF 1613
Query: 1647 AAKILEVVPSERIKAALDDPAVWDSYAADDQKLGRLLLTELLSWQFASPVRWIETQALLF 1706
+I ++VP+E + L D W +++ R + ELL+WQFASPVRWIETQ LLF
Sbjct: 1614 IQEIRDLVPAEPLDEILADYDTW--LRERPREMARTVFIELLAWQFASPVRWIETQDLLF 1671
Query: 1707 GKREQGGLGVEEYVEVGLGNAPTLANLGAKTLRLPEFAGNDTVVYNVGRDEGRVYMTDTD 1766
+ GGLGVE +VE+G+ ++PT+A L TL+LPE+A + V N RD ++ TDTD
Sbjct: 1672 IEEAAGGLGVERFVEIGVKSSPTVAGLATNTLKLPEYAHSTVEVLNAERDAAVLFATDTD 1731
Query: 1767 SLVPDDEPEETAAPVETAPAGGSAVAKLGSSAAADAAPAAAAAPAPAAPVSAAPAGAPSG 1826
P+ EPEE PV +PA ++AAP APA + +G
Sbjct: 1732 ---PEPEPEED-EPVAESPA---------PDVVSEAAP-------------VAPAASSAG 1765
Query: 1827 AAVADLPFKASDGIGVLMAYAAKVRLDQIGSNDTTDTLTNGVSSRRNQLLMDISSELGVA 1886
DL F A+D L+A +AK+R+DQI D+ +++T+G SSRRNQLL+D+ SEL +
Sbjct: 1766 PRPDDLVFDAADATLALIALSAKMRIDQIEELDSIESITDGASSRRNQLLVDLGSELNLG 1825
Query: 1887 SVDGAAEATLDKLAQIVNKAAPNYKPFGAVLSEALRDRLRSLFGAAGVKQQYIRDRVANV 1946
++DGAAE+ L L V K A YKP+G VLS+A+ D+LR++ G +G + I +RV
Sbjct: 1826 AIDGAAESDLAGLRSQVTKLARTYKPYGPVLSDAINDQLRTVLGPSGKRPGAIAERVKKT 1885
Query: 1947 WQLGEGWVASVLAALLLDTREGSSSRGGDLAKLPTAAVQNKPEADKLIDAAVEVVAQLKG 2006
W+LGEGW V + L TREGSS RGG + L A+ + DK+IDAAV VA +G
Sbjct: 1886 WELGEGWAKHVTVEVALGTREGSSVRGGAMGHLHEGALADAASVDKVIDAAVASVAARQG 1945
Query: 2007 VAVALPSAGGAAGGAVVDSAALDAFAEKVTGSNGVLAATARFVLNELGVAAPAPEESEDE 2066
V+VALPSA G+ GGA +D+AAL F +++TG GVLA+ AR VL +LG+ P
Sbjct: 1946 VSVALPSA-GSGGGATIDAAALSEFTDQITGREGVLASAARLVLGQLGLDDPVNALPAAP 2004
Query: 2067 NAAVVAAVEAELGSDWPKQVAPRFDANKAILFDDRWASAREDLARAY------YDNDPAA 2120
++ ++ V AELG+DWP+ VAP FD KA++FDDRWASAREDL + + D D
Sbjct: 2005 DSELIDLVTAELGADWPRLVAPVFDPKKAVVFDDRWASAREDLVKLWLTDEGDIDADWPR 2064
Query: 2121 LNGSFIGLGKTIAAEAQWFADKSNNDELKAAFQKAAS--EALESVTSDKNASRYANDIAI 2178
L F G G +A +A W+ KS L A Q AS + + + RY ++A+
Sbjct: 2065 LAERFEGAGHVVATQATWWQGKS----LAAGRQIHASLYGRIAAGAENPEPGRYGGEVAV 2120
Query: 2179 VTGVSPNSIAAQVVEGLLAGGATVVATSHSFKPSIKAWAKQAYREHATGNAKLWLVPANL 2238
VTG S SIAA VV LL GGATV+AT+ A+ + YR+HA A LWLV AN+
Sbjct: 2121 VTGASKGSIAASVVARLLDGGATVIATTSKLDEERLAFYRTLYRDHARYGAALWLVAANM 2180
Query: 2239 SSYRDVDALVDWVGHEQKKTSGATTTILKPAWEPTLFFPFAAPPVHGTLADSGDLFESQA 2298
+SY DVDALV+W+G EQ ++ G + +K A PTL FPFAAP V G L+++G E +
Sbjct: 2181 ASYSDVDALVEWIGTEQTESLGPQSIHIKDAQTPTLLFPFAAPRVVGDLSEAGSRAEMEM 2240
Query: 2299 RLMLWGVERAIAGFSHIGADANVQHKLHVVLPGSPNRGVFGGDGAYGEVKSAFDAIVNRA 2358
+++LW V+R I G S IGA+ ++ +LHVVLPGSPNRG+FGGDGAYGE KSA DA+V+R
Sbjct: 2241 KVLLWAVQRLIGGLSTIGAERDIASRLHVVLPGSPNRGMFGGDGAYGEAKSALDAVVSRW 2300
Query: 2359 RAEKVWSSRVTFAHPKIGWVRGTGLMGGNDPLVAVVERHGIHTYSTAQIAAKLLDLCTAE 2418
AE W++RV+ AH IGW RGTGLMG ND +VA VE G+ TYST ++AA LLDLC AE
Sbjct: 2301 HAESSWAARVSLAHALIGWTRGTGLMGHNDAIVAAVEEAGVTTYSTDEMAALLLDLCDAE 2360
Query: 2419 SREQALKAPLNVDLTGGLGSEPIDIKALRTEAMADAEKEASSEKAAIEGEKPEGGAAGST 2478
S+ A ++P+ DLTGGL +D+ L +A +E S AA++ E A
Sbjct: 2361 SKVAAARSPIKADLTGGLAEANLDMAELAAKA-----REQMSAAAAVD----EDAEAPGA 2411
Query: 2479 LKALPTPIVTKQAPVDLADWQNVTARPEDEIVIVSVGELGPWGSGRTRAQAELGIHSDGT 2538
+ ALP+P P W ++ P D +VIV E+GP+GS RTR + E+
Sbjct: 2412 IAALPSP-PRGFTPAPPPQWDDLDVDPADLVVIVGGAEIGPYGSSRTRFEMEV------E 2464
Query: 2539 VDLSAGAVLELAWNMGLLTWADSPKPGWYDTD-GNLVPEEDIAERYHDEVVARSGIRPFE 2597
+LSA VLELAW GL+ W D P+PGWYDT+ G +V E ++ +RYHD VV R GIR F
Sbjct: 2465 NELSAAGVLELAWTTGLIRWEDDPQPGWYDTESGEMVDESELVQRYHDAVVQRVGIREFV 2524
Query: 2598 EGMGDDYKDGADEEEAEVFLDHDVTFSVPTREVAAEYVKLDEAHTTIAPDEESGEWNVTR 2657
+ D D A VFL+ D F V + A +V+ D HT I P +S +W V R
Sbjct: 2525 DDGAID-PDHASPLLVSVFLEKDFAFVVSSEADARAFVEFDPEHTVIRPVPDSTDWQVIR 2583
Query: 2658 HAGSMIRVPRRATMTRTVGGQFPKGFDPTRWGIPASMVGDVDKIALWNIVTTVDAYLGAG 2717
AG+ IRVPR+ ++R VGGQ P GFDPT WGI A M G +D++A+WN+V TVDA+L +G
Sbjct: 2584 KAGTEIRVPRKTKLSRVVGGQIPTGFDPTVWGISADMAGSIDRLAVWNMVATVDAFLSSG 2643
Query: 2718 FTPAEILESIHPSLVASTQGTGFGGMMSMRKLYLDRFLNHEIPTDILQEALPNVVAAHVM 2777
F+PAE++ +HPSLVA+TQGTG GG SM+ +Y L P DI QE LPN++AAHV+
Sbjct: 2644 FSPAEVMRYVHPSLVANTQGTGMGGGTSMQTMYHGNLLGRNKPNDIFQEVLPNIIAAHVV 2703
Query: 2778 QSYIGGYGNMIQPVSACATAAVSLEEGVDKIALGKADFVVTGAIDDIGVESVIGFGNMNA 2837
QSY+G YG MI PV+ACATAAVS+EEGVDKI LGKA VV G +DD+ +E +IGFG+M A
Sbjct: 2704 QSYVGSYGAMIHPVAACATAAVSVEEGVDKIRLGKAQLVVAGGLDDLTLEGIIGFGDMAA 2763
Query: 2838 TANSEEMYGKGIDARFFSRANDRRRGGFLESQGGGTILVTRGDIAEKLGLPVAAVVGFIH 2897
TA++ M G+GI FSR NDRRR GF+E+QGGGTIL+ RGD+A ++GLPV AVV F
Sbjct: 2764 TADTSMMCGRGIHDSKFSRPNDRRRLGFVEAQGGGTILLARGDLALRMGLPVLAVVAFAQ 2823
Query: 2898 SYADGAHTSIPAPGLGALAAGMGGEDSKLVRDLAKLGVSADDIAVVSKHDTSTNANDPNE 2957
S+ DG HTSIPAPGLGAL AG GG+DS L R LAKLGV+ADD+AV+SKHDTST ANDPNE
Sbjct: 2824 SFGDGVHTSIPAPGLGALGAGRGGKDSPLARALAKLGVAADDVAVISKHDTSTLANDPNE 2883
Query: 2958 SELHNTLAHAIGRTDGNPLFVISQKTLTGHAKGGACIFQVNGLTQLFKSGVIPANVSLDC 3017
+ELH LA A+GR++G PLFV+SQK+LTGHAKGGA +FQ+ GL Q+ + GVIP N SLDC
Sbjct: 2884 TELHERLADALGRSEGAPLFVVSQKSLTGHAKGGAAVFQMMGLCQILRDGVIPPNRSLDC 2943
Query: 3018 VDPKLQRDDHMVWVRKPLRIGGGEDEFGRETAGRPVKAGLATSLGFGHVSGFVALVHPGA 3077
VD +L H VWVR LR+GG +F P+KAG+ TSLGFGHVSG VALVHP A
Sbjct: 2944 VDDELAGSAHFVWVRDTLRLGG---KF-------PLKAGMLTSLGFGHVSGLVALVHPQA 2993
Query: 3078 FEAAVAKADGEAALEAWRERANARLVAGQRHLEEGMMGRAALYEPIDNRRFHEDHRGYDH 3137
F A++ A ++ RA+ARL+AGQR L + G A +Y+ +RRF DH
Sbjct: 2994 FIASL----DPAQRADYQRRADARLLAGQRRLASAIAGGAPMYQRPGDRRF-------DH 3042
Query: 3138 HEVEK----AMLLNPDARLG 3153
H E+ +MLLNP ARLG
Sbjct: 3043 HAPERPQEASMLLNPAARLG 3062