Pairwise Alignments

Query, 3160 a.a., type I polyketide synthase from Bifidobacterium breve UCC2003

Subject, 4151 a.a., Polyketide synthase Pks12 from Mycobacterium tuberculosis H37Rv

 Score = 74.3 bits (181), Expect = 5e-16
 Identities = 161/696 (23%), Positives = 257/696 (36%), Gaps = 99/696 (14%)

Query: 2340 GDGAYGEVKSAFDAIVNRARAEKVWSSRVTFAHPKIGWVRGTGLMGGNDPL-VAVVERHG 2398
            G   Y    S  DA+    RA  + +  + +      W + + + GG D   +A + R G
Sbjct: 1824 GQANYAAANSFLDALAAHRRAHGLPAISLGWGL----WDQASAMTGGLDAADLARLGREG 1879

Query: 2399 IHTYSTAQIAAKLLDLCTAESREQALKAPLNVDLTGGLGSEPIDIKALRTEAMADAEKEA 2458
            +   STA+ A +L D  TA   ++   AP  +DLT           ALR  A+A     +
Sbjct: 1880 VLALSTAE-ALELFD--TAMIVDEPFLAPARIDLT-----------ALRAHAVAVPPMFS 1925

Query: 2459 SSEKAAIEGEKPEGGAAGSTLKALPTPIVTKQAPVDLADWQNVTARPEDEIVIVSVGELG 2518
                A    +  +  AA  +  AL      +   +  A+   V        +   +G + 
Sbjct: 1926 DLASAPTRRQVDDSVAAAKSKSAL----AHRLHGLPEAEQHAVLLGLVRLHIATVLGNIT 1981

Query: 2519 PWGSGRTRAQAELGIHSDGTVDLSAGAVLELAWNMGLLTWADSPKPG----WYDTDGNLV 2574
            P      +A  +LG  S   V++          ++      D P P     +  T+   +
Sbjct: 1982 PEAIDPDKAFQDLGFDSLTAVEMRNRLKSATGLSLSPTLIFDYPTPNRLASYIRTELAGL 2041

Query: 2575 PEEDIAERYHDEVVARSGIRPFE-EGMGDDYKDGADEEEAEVFLDHDVTFSVPTREVAAE 2633
            P+E      H   V  +   P    GM   Y  G +        D      +  R+V +E
Sbjct: 2042 PQEI----KHTPAVRTTSEDPIAIVGMACRYPGGVNSP------DDMWDMLIQGRDVLSE 2091

Query: 2634 YVKLDEAHTTIAPDEESGEWNVTRHAGSMIRVPRRATMTRTVGGQFPKG---FDPTRWGI 2690
            +           P +    W++   AG     P  A    T  G F  G   FDP  +G+
Sbjct: 2092 F-----------PADRG--WDL---AGLYNPDPDAAGACYTRTGGFVDGVGDFDPAFFGV 2135

Query: 2691 PASMVGDVDKIALWNIVTTVDAYLGAGFTPAEILESIHPSLVASTQGTGFGGMMSMRKLY 2750
              S    +D      +  + +A   AG  P  +  S    + A     G+G         
Sbjct: 2136 GPSEALAMDPQHRMLLELSWEALERAGIDPTGLRGSA-TGVFAGVMTQGYG--------- 2185

Query: 2751 LDRFLNHEIPTDILQEALPNVVAAHVMQSYIGGYGNMIQPVSACATAAVSLEEGVDKIAL 2810
               F    +    L   L +V +  V    +G  G  +   +AC+++ V+L   V  +  
Sbjct: 2186 --MFAAEPVEGFRLTGQLSSVASGRVAY-VLGLEGPAVSVDTACSSSLVALHMAVGSLRS 2242

Query: 2811 GKADFVVTGAIDDIGVESVIGFGNMNATANS----EEMYGKGIDARFFSRANDRRRGGFL 2866
            G+ D  + G +             +NAT +         G   D R  + A      GF 
Sbjct: 2243 GECDLALAGGV------------TVNATPDIFVEFSRWRGLSPDGRCKAFAAAADGTGF- 2289

Query: 2867 ESQGGGTILVTRGDIAEKLGLPVAAVVGFIHSYADGAHTSIPAPGLGALAAGMGGEDSKL 2926
             S+GGG +++ R   A +LG PV AVV       DGA   + AP         G    ++
Sbjct: 2290 -SEGGGMLVLQRLSDARRLGHPVLAVVVGSAVNQDGASNGLTAPN--------GPSQQRV 2340

Query: 2927 VR-DLAKLGVSADDIAVVSKHDTSTNANDPNESE-LHNTLAHAIGRTDGNPLFVISQKTL 2984
            VR  LA  G+SA ++ VV  H T T   DP E++ L  T     G   G PL++ S K+ 
Sbjct: 2341 VRAALANAGLSAAEVDVVEGHGTGTTLGDPIEAQALLATYGQDRGE-PGEPLWLGSVKSN 2399

Query: 2985 TGHAKGGACIFQVNGLTQLFKSGVIPANVSLDCVDP 3020
             GH +  A +  V  +    +  ++PA + +D   P
Sbjct: 2400 MGHTQAAAGVAGVIKMVLAMRHELLPATLHVDVPSP 2435



 Score = 71.6 bits (174), Expect = 3e-15
 Identities = 68/251 (27%), Positives = 108/251 (43%), Gaps = 21/251 (8%)

Query: 2772 VAAHVMQSYIGGYGNMIQPVSACATAAVSLEEGVDKIALGKADFVVTGAIDDIGVESVIG 2831
            VA+  +   +G  G  +   +AC+++ V+L   V  +  G+ D  + G +          
Sbjct: 181  VASGRVAYVLGLEGPAVSVDTACSSSLVALHMAVGSLRSGECDLALAGGVTV-------- 232

Query: 2832 FGNMNATANSEEMYGKGIDARFFSRANDRRRGGFLESQGGGTILVTRGDIAEKLGLPVAA 2891
              N   T   E    +G+      +    R  G   S+GGG +++ R   A +LG PV A
Sbjct: 233  --NATPTVFVEFSRHRGLAPDGRCKPYAGRADGVGWSEGGGMLVLQRLSDARRLGHPVLA 290

Query: 2892 VVGFIHSYADGAHTSIPAPGLGALAAGMGGEDSKLVR-DLAKLGVSADDIAVVSKHDTST 2950
            VV       DGA   + AP         G    ++VR  LA  G+SA ++ VV  H T T
Sbjct: 291  VVVGSAVNQDGASNGLTAPN--------GPSQQRVVRAALANAGLSAAEVDVVEGHGTGT 342

Query: 2951 NANDPNESE-LHNTLAHAIGRTDGNPLFVISQKTLTGHAKGGACIFQVNGLTQLFKSGVI 3009
               DP E++ L  T     G   G PL++ S K+  GH +  A +  V  +    +  ++
Sbjct: 343  TLGDPIEAQALLATYGQDRGE-PGEPLWLGSVKSNMGHTQAAAGVAGVIKMVLAMRHELL 401

Query: 3010 PANVSLDCVDP 3020
            PA + +D   P
Sbjct: 402  PATLHVDVPSP 412



 Score = 55.8 bits (133), Expect = 2e-10
 Identities = 54/155 (34%), Positives = 70/155 (45%), Gaps = 17/155 (10%)

Query: 1349 GQLVSRGTALVRAPRAAFVYPGQGIQKQGMVLDERAKSAAARDVWERADKLTRAKLGFSI 1408
            G  V RGTA   A +  FV+PGQG Q  GM +   A       V+  A      +L   +
Sbjct: 2567 GGSVVRGTATA-AGKTVFVFPGQGSQWLGMGMGLHA----GYPVFAEAFNTVVGELDRHL 2621

Query: 1409 LGLVRDNPKELTANGVTYRHPEGLLNLTQFTQVALATVAFAQTARLREAGADIWPAYFAG 1468
            L  +R+         V + H E LLN T+F Q AL  V  A    L   G  + P +  G
Sbjct: 2622 LRPLRE---------VMWGHDENLLNSTEFAQPALFAVEVALFRLLGSWG--VRPDFVMG 2670

Query: 1469 HSLGEYNALSAFADVIPLETVLELVFHRGSTMHHL 1503
            HS+GE +A +  A V+ LE    LV  RG  M  L
Sbjct: 2671 HSIGELSA-AHVAGVLSLENAAVLVAARGRLMQAL 2704