MetaCyc Pathway: methyl-coenzyme M oxidation to CO<sub>2</sub> II in Methanococcus maripaludis S2

MetaCyc Pathway: methyl-coenzyme M oxidation to CO₂ II in Methanococcus maripaludis S2

Tetrahydromethanopterin S-methyltransferase (in reverse):
methyl-CoM_[in] + tetrahydromethanopterin_[in] + 2 Na⁺_[out]→5-methyltetrahydromethanopterin_[in] + coenzyme M_[in] + 2 Na⁺_[in] (EC 2.1.1.86)

5-methyltetrahydromethanopterin + an oxidized factor 420→5,10-methylene-tetrahydromethanopterin + a reduced factor 420 (EC 1.5.98.2)

5,10-methylene-tetrahydromethanopterin + an oxidized factor 420 + H⁺→5,10-methenyltetrahydromethanopterin + a reduced factor 420 (EC 1.5.98.1)

Methenyltetrahydromethanopterin cyclohydrolase:
5,10-methenyltetrahydromethanopterin + H₂O→5-formyl-tetrahydromethanopterin + H⁺ (EC 3.5.4.27)

Formylmethanofuran--tetrahydromethanopterin N-formyltransferase (in reverse):
5-formyl-tetrahydromethanopterin + a methanofuran→tetrahydromethanopterin + a formylmethanofuran + H⁺ (EC 2.3.1.101)

a formylmethanofuran + 2 an oxidized ferredoxin [iron-sulfur] cluster + H₂O→a methanofuran + CO₂ + H⁺ + 2 a reduced ferredoxin [iron-sulfur] cluster (EC 1.2.7.12)

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Pathway details at MetaCyc
Fitness data for 19 genes
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All MetaCyc pathways for Methanococcus maripaludis S2

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information