MetaCyc Pathway: methanogenesis from H<SUB>2</SUB> and CO<SUB>2</SUB> in Methanococcus maripaludis S2

MetaCyc Pathway: methanogenesis from H₂ and CO₂ in Methanococcus maripaludis S2

CO₂ + a methanofuran + H⁺ + 2 a reduced ferredoxin [iron-sulfur] cluster→a formylmethanofuran + 2 an oxidized ferredoxin [iron-sulfur] cluster + H₂O (EC 1.2.7.12)

Formylmethanofuran--tetrahydromethanopterin N-formyltransferase:
a formylmethanofuran + H⁺ + tetrahydromethanopterin→5-formyl-tetrahydromethanopterin + a methanofuran (EC 2.3.1.101)

Methenyltetrahydromethanopterin cyclohydrolase (in reverse):
5-formyl-tetrahydromethanopterin + H⁺→5,10-methenyltetrahydromethanopterin + H₂O (EC 3.5.4.27)

5,10-methenyltetrahydromethanopterin hydrogenase:
5,10-methenyltetrahydromethanopterin + H₂→5,10-methylene-tetrahydromethanopterin + H⁺ (EC 1.12.98.2)

5,10-methylene-tetrahydromethanopterin + a reduced factor 420→5-methyltetrahydromethanopterin + an oxidized factor 420 (EC 1.5.98.2)

Tetrahydromethanopterin S-methyltransferase:
5-methyltetrahydromethanopterin_[in] + coenzyme M_[in] + 2 Na⁺_[in]→methyl-CoM_[in] + 2 Na⁺_[out] + tetrahydromethanopterin_[in] (EC 2.1.1.86)

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Pathway details at MetaCyc
Fitness data for 19 genes
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All MetaCyc pathways for Methanococcus maripaludis S2

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information