MetaCyc Pathway: toluene degradation II (aerobic) (via 4-methylcatechol) in Cupriavidus basilensis FW507-4G11

Add experiment(s):


toluene + NADH + dioxygen + H+→4-methylphenol + NAD+ + H2O (EC 1.14.13.236)
No genes
4-methylphenol + NADH + dioxygen + H+→4-methylcatechol + NAD+ + H2O (EC 1.14.13.236)
No genes
Catechol 2,3-dioxygenase:
4-methylcatechol + dioxygen→(2Z,4E)-2-hydroxy-5-methyl-6-oxohexa-2,4-dienoate + H+ (EC 1.13.11.2)
RR42_RS32655
RR42_RS34600
(2Z,4E)-2-hydroxy-5-methyl-6-oxohexa-2,4-dienoate + H2O→(2Z)-2-hydroxyhexa-2,5-dienoate + formate + H+ (EC 3.7.1.25)
No genes
2-oxopent-4-enoate hydratase (in reverse):
(2Z)-2-hydroxyhexa-2,5-dienoate + H2O→(S)-4-hydroxy-2-oxohexanoate (EC 4.2.1.80)
RR42_RS05105
RR42_RS27885
RR42_RS32645
RR42_RS34355
(S)-4-hydroxy-2-oxohexanoate→1-propanal + pyruvate (EC 4.1.3.43)
RR42_RS31860

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information