MetaCyc Pathway: TCA cycle VI (Helicobacter) in Cupriavidus basilensis FW507-4G11

Add experiment(s):


2-oxoglutarate synthase:
2-oxoglutarate + coenzyme A + 2 an oxidized ferredoxin [iron-sulfur] cluster→succinyl-CoA + CO2 + H+ + 2 a reduced ferredoxin [iron-sulfur] cluster (EC 1.2.7.3)
No genes
3-oxoacid CoA-transferase:
succinyl-CoA + acetoacetate→succinate + acetoacetyl-CoA (EC 2.8.3.5)
RR42_RS06555
RR42_RS06560
Succinate dehydrogenase (ubiquinone) (in reverse):
succinate[in] + a menaquinone→fumarate[in] + a menaquinol (EC 1.3.5.1)
No genes
Fumarate hydratase (in reverse):
fumarate + H2O→(S)-malate (EC 4.2.1.2)
RR42_RS02195
RR42_RS13905
RR42_RS27740
RR42_RS33090
RR42_RS37365
(S)-malate + a menaquinone→oxaloacetate + a menaquinol (EC 1.1.5.4)
No genes
Citrate (Si)-synthase:
oxaloacetate + acetyl-CoA + H2O→citrate + coenzyme A + H+ (EC 2.3.3.1; 2.3.3.16; 2.3.3.3)
RR42_RS09325
RR42_RS10505
RR42_RS14430
RR42_RS32385
RR42_RS36245
Aconitate hydratase:
citrate→cis-aconitate + H2O (EC 4.2.1.3)
RR42_RS11270
RR42_RS14490
RR42_RS23515
Aconitate hydratase:
cis-aconitate + H2O→D-threo-isocitrate (EC 4.2.1.3)
RR42_RS11270
RR42_RS14490
RR42_RS23515
Isocitrate dehydrogenase (NADP(+)):
D-threo-isocitrate + NADP+→2-oxoglutarate + CO2 + NADPH (EC 1.1.1.42)
RR42_RS17135
RR42_RS22955
RR42_RS28800
RR42_RS29535

Links:

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information