MetaCyc Pathway: superpathway of purine nucleotide salvage in Cupriavidus basilensis FW507-4G11

Add experiment(s):


Adenosine kinase:
adenosine + ATP→AMP + ADP + H+ (EC 2.7.1.20)
RR42_RS17720
Purine-nucleoside phosphorylase:
adenosine + phosphate→adenine + α-D-ribose-1-phosphate (EC 2.4.2.1)
No genes
Adenylosuccinate synthase:
IMP + L-aspartate + GTP→adenylosuccinate + GDP + 2 H+ + phosphate (EC 6.3.4.4)
RR42_RS13090
IMP dehydrogenase:
IMP + NAD+ + H2O→XMP + NADH + H+ (EC 1.1.1.205)
RR42_RS00320
RR42_RS06470
RR42_RS11750
Purine-nucleoside phosphorylase:
guanosine + phosphate→guanine + α-D-ribose-1-phosphate (EC 2.4.2.1; 2.4.2.15)
No genes
Adenine phosphoribosyltransferase (in reverse):
adenine + 5-phospho-α-D-ribose 1-diphosphate→AMP + diphosphate (EC 2.4.2.7)
RR42_RS02125
Adenylosuccinate lyase:
adenylosuccinate→AMP + fumarate (EC 4.3.2.2)
RR42_RS17455
GMP synthase (glutamine-hydrolyzing):
XMP + ATP + L-glutamine + H2O→GMP + AMP + L-glutamate + diphosphate + 2 H+ (EC 6.3.5.2)
RR42_RS11740
Hypoxanthine phosphoribosyltransferase (in reverse):
guanine + 5-phospho-α-D-ribose 1-diphosphate→GMP + diphosphate (EC 2.4.2.8)
RR42_RS02125
RR42_RS13085
RR42_RS17895
Adenylate kinase:
AMP + ATP→2 ADP (EC 2.7.4.3)
RR42_RS03445
Guanylate kinase:
GMP + ATP→GDP + ADP (EC 2.7.4.8)
RR42_RS04905
RR42_RS04910
RR42_RS28065
Ribonucleoside-diphosphate reductase (in reverse):
ADP + a reduced thioredoxin→dADP + an oxidized thioredoxin + H2O (EC 1.17.4.1)
RR42_RS13290
RR42_RS17855
RR42_RS17860
Nucleoside-diphosphate kinase:
GDP + ATP→GTP + ADP (EC 2.7.4.6)
RR42_RS03445
RR42_RS13160
Nucleoside-diphosphate kinase:
dADP + ATP→ADP + dATP (EC 2.7.4.6)
RR42_RS13160

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information