MetaCyc Pathway: androgen biosynthesis in Cupriavidus basilensis FW507-4G11

Add experiment(s):


pregnenolone + dioxygen + a reduced [NADPH-hemoprotein reductase]→17-α-hydroxypregnenolone + an oxidized [NADPH-hemoprotein reductase] + H2O (EC 1.14.14.19)
No genes
17-α-hydroxypregnenolone + dioxygen + a reduced [NADPH-hemoprotein reductase]→3-β-hydroxyandrost-5-en-17-one + acetate + an oxidized [NADPH-hemoprotein reductase] + H+ + H2O (EC 1.14.14.32)
No genes
3-beta-hydroxy-Delta(5)-steroid dehydrogenase:
3-β-hydroxyandrost-5-en-17-one + NAD+→androst-5-ene-3,17-dione + NADH + H+ (EC 1.1.1.145)
No genes
Steroid Delta-isomerase:
androst-5-ene-3,17-dione→androstenedione (EC 5.3.3.1)
RR42_RS31815
Testosterone 17-beta-dehydrogenase (NADP(+)) (in reverse):
androstenedione + NADPH + H+→testosterone + NADP+ (EC 1.1.1.64)
No genes
Cholestenone 5-alpha-reductase (in reverse):
testosterone + NADPH + H+→5α-dihydrotestosterone + NADP+ (EC 1.3.1.22)
No genes

Links:

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information