MetaCyc Pathway: leukotriene biosynthesis in Cupriavidus basilensis FW507-4G11

Add experiment(s):


Arachidonate 5-lipoxygenase:
arachidonate + dioxygen→(5S)-HpETE (EC 1.13.11.34)
No genes
Arachidonate 5-lipoxygenase:
(5S)-HpETE→leukotriene A4 + H2O (EC 1.13.11.34)
No genes
Leukotriene-A(4) hydrolase:
leukotriene A4 + H2O→leukotriene B4 (EC 3.3.2.6)
No genes
Leukotriene-C(4) synthase (in reverse):
leukotriene A4 + glutathione→leukotriene C4 (EC 4.4.1.20)
No genes
Gamma-glutamyltransferase:
leukotriene C4 + a proteinogenic amino acid→leukotriene D4 + an α-(γ-L-glutamyl)-L-amino acid (EC 2.3.2.2)
RR42_RS05040
RR42_RS15195
RR42_RS23025
RR42_RS26175
RR42_RS27305
RR42_RS32275
Membrane dipeptidase:
leukotriene D4 + H2O→leukotriene E4 + glycine (EC 3.4.13.19)
RR42_RS22235

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information