MetaCyc Pathway: catecholamine biosynthesis in Cupriavidus basilensis FW507-4G11

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Tyrosine 3-monooxygenase:
L-tyrosine + dioxygen + 5,6,7,8-tetrahydrobiopterin→L-dopa + a 4a-hydroxytetrahydrobiopterin (EC 1.14.16.2)
No genes
Aromatic-L-amino-acid decarboxylase:
L-dopa + H+→dopamine + CO2 (EC 4.1.1.28)
RR42_RS26695
Dopamine beta-monooxygenase:
dopamine + 2 L-ascorbate + dioxygen + 2 H+→(R)-noradrenaline + 2 monodehydroascorbate radical + H2O (EC 1.14.17.1)
No genes
Phenylethanolamine N-methyltransferase:
(R)-noradrenaline + S-adenosyl-L-methionine→(R)-adrenaline + S-adenosyl-L-homocysteine + H+ (EC 2.1.1.28)
No genes

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information