MetaCyc Pathway: nicotine degradation V in Cupriavidus basilensis FW507-4G11

Add experiment(s):


(S)-nicotine + dioxygen + a reduced [NADPH-hemoprotein reductase]→nicotine-Δ1'5'-iminium ion + an oxidized [NADPH-hemoprotein reductase] + 2 H2O
No genes
nicotine-Δ1'5'-iminium ion + dioxygen + H2O→cotinine + hydrogen peroxide + H+
No genes
Unspecific monooxygenase:
cotinine + dioxygen + a reduced [NADPH-hemoprotein reductase]→trans-3'-hydroxycotinine + an oxidized [NADPH-hemoprotein reductase] + H2O (EC 1.14.14.1)
RR42_RS19955
Unspecific monooxygenase:
cotinine + dioxygen + a reduced [NADPH-hemoprotein reductase]→5'-hydroxycotinine + an oxidized [NADPH-hemoprotein reductase] + H2O (EC 1.14.14.1)
RR42_RS19955
cotinine→cotinine N-oxide
No genes
cotinine→cotinine methonium ion
No genes
Glucuronosyltransferase:
cotinine + UDP-α-D-glucuronate→cotinine-glucuronide + UDP (EC 2.4.1.17)
No genes
Unspecific monooxygenase:
cotinine + dioxygen + a reduced [NADPH-hemoprotein reductase]→N'-hydroxymethyl-norcotinine + an oxidized [NADPH-hemoprotein reductase] + H2O (EC 1.14.14.1)
RR42_RS19955
Glucuronosyltransferase:
trans-3'-hydroxycotinine + UDP-α-D-glucuronate→trans-3-hydroxycotinine-glucuronide + H+ + UDP (EC 2.4.1.17)
No genes
5'-hydroxycotinine→4-oxo-4-(3-pyridyl)-N-methylbutanamide
No genes
N'-hydroxymethyl-norcotinine + dioxygen + a [reduced flavoprotein]→norcotinine + an [oxidized flavoprotein] + H2O
No genes
norcotinine→4-oxo-4-(3-pyridyl)-butanamide
No genes
4-oxo-4-(3-pyridyl)-N-methylbutanamide→4-oxo-4-(3-pyridyl)-butanoate
No genes
4-oxo-4-(3-pyridyl)-butanamide→4-oxo-4-(3-pyridyl)-butanoate
No genes
4-oxo-4-(3-pyridyl)-butanoate + a reduced two electron carrier→4-hydroxy-4-(3-pyridyl)-butanoate + an oxidized electron carrier
No genes
4-hydroxy-4-(3-pyridyl)-butanoate→4-(3-pyridyl)-3-butenoate
No genes
4-(3-pyridyl)-3-butenoate + a reduced two electron carrier→4-(3-pyridyl)-butanoate + an oxidized electron carrier
No genes
4-(3-pyridyl)-butanoate→3-pyridylacetate
No genes

Links:

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information