MetaCyc Pathway: nicotine degradation IV in Cupriavidus basilensis FW507-4G11

Add experiment(s):


(S)-nicotine + an oxidized electron carrier + H2O→(S)-nornicotine + a reduced two electron carrier + formaldehyde
No genes
Unspecific monooxygenase:
(S)-nicotine + dioxygen + a reduced [NADPH-hemoprotein reductase]→2'-hydroxynicotine + an oxidized [NADPH-hemoprotein reductase] + H2O (EC 1.14.14.1)
RR42_RS19955
(S)-nicotine + dioxygen + a reduced [NADPH-hemoprotein reductase]→nicotine-Δ1'5'-iminium ion + an oxidized [NADPH-hemoprotein reductase] + 2 H2O
No genes
(S)-nornicotine + 2 an oxidized electron carrier + H2O→norcotinine + 2 a reduced two electron carrier + H+
No genes
2'-hydroxynicotine→pseudooxynicotine
No genes
nicotine-Δ1'5'-iminium ion + dioxygen + H2O→cotinine + hydrogen peroxide + H+
No genes
Flavin-containing monooxygenase:
(S)-nicotine + NADPH + dioxygen→trans-(S)-nicotine N1'-oxide + NADP+ + H2O (EC 1.14.13.8)
No genes
Glucuronosyltransferase:
(S)-nicotine + UDP-α-D-glucuronate→nicotine-glucuronide + UDP (EC 2.4.1.17)
No genes
pseudooxynicotine + 2 an oxidized c-type cytochrome + H2O→4-oxo-4-(pyridin-3-yl)butanal + 2 a reduced c-type cytochrome + methylamine + 2 H+ (EC 1.4.2.3)
No genes
norcotinine→4-oxo-4-(3-pyridyl)-butanamide
No genes
4-oxo-4-(pyridin-3-yl)butanal + NADP+ + H2O→4-oxo-4-(3-pyridyl)-butanoate + NADPH + 2 H+ (EC 1.2.1.83)
No genes
4-oxo-4-(3-pyridyl)-butanamide→4-oxo-4-(3-pyridyl)-butanoate
No genes
4-oxo-4-(3-pyridyl)-butanoate + a reduced two electron carrier→4-hydroxy-4-(3-pyridyl)-butanoate + an oxidized electron carrier
No genes
4-hydroxy-4-(3-pyridyl)-butanoate→4-(3-pyridyl)-3-butenoate
No genes
4-(3-pyridyl)-3-butenoate + a reduced two electron carrier→4-(3-pyridyl)-butanoate + an oxidized electron carrier
No genes
4-(3-pyridyl)-butanoate→3-pyridylacetate
No genes

Links:

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information