MetaCyc Pathway: L-ascorbate biosynthesis IV (animals, D-glucuronate pathway) in Cupriavidus basilensis FW507-4G11

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UDP-α-D-glucuronate + H2O→D-glucopyranuronate + H+ + UDP
No genes
D-glucopyranuronate→aldehydo-D-glucuronate (spontaneous)
No genes
Glucuronate reductase (in reverse):
aldehydo-D-glucuronate + NADPH + H+→L-gulonate + NADP+ (EC 1.1.1.19)
No genes
Gluconolactonase (in reverse):
L-gulonate + H+→L-gulono-1,4-lactone + H2O (EC 3.1.1.17)
RR42_RS09940
RR42_RS23435
RR42_RS26550
RR42_RS27020
RR42_RS33665
L-gulonolactone oxidase:
L-gulono-1,4-lactone + dioxygen→L-xylo-hex-3-ulono-1,4-lactone + hydrogen peroxide (EC 1.1.3.8)
No genes
L-gulonolactone oxidase:
L-xylo-hex-3-ulono-1,4-lactone→L-ascorbate + H+ (spontaneous) (EC 1.1.3.8)
No genes

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information