MetaCyc Pathway: superpathway of fatty acid biosynthesis I (E. coli) in Cupriavidus basilensis FW507-4G11

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[Acyl-carrier-protein] S-acetyltransferase:
acetyl-CoA + a soluble [acyl-carrier protein]→an acetyl-[acp] + coenzyme A
(EC 2.3.1.38)
No genes
acetyl-CoA + a [carboxyl-carrier protein dimer]-N6-carboxybiotinyl-L-lysine→malonyl-CoA + a [biotin carboxyl-carrier-protein dimer]-N6-biotinyl-L-lysine (EC 2.1.3.15)
RR42_RS06360
RR42_RS14345
[Acyl-carrier-protein] S-malonyltransferase:
malonyl-CoA + a soluble [acyl-carrier protein]→a malonyl-[acp] + coenzyme A
(EC 2.3.1.39)
RR42_RS02935
RR42_RS14105
Beta-ketoacyl-acyl-carrier-protein synthase III:
acetyl-CoA + a malonyl-[acp] + H+→an acetoacetyl-[acp] + CO2 + coenzyme A
(EC 2.3.1.180)
RR42_RS14110
Beta-ketoacyl-acyl-carrier-protein synthase II:
an acetyl-[acp] + a malonyl-[acp] + H+→an acetoacetyl-[acp] + a soluble [acyl-carrier protein] + CO2
(EC 2.3.1.179; 2.3.1.41)
RR42_RS14090
RR42_RS31185
RR42_RS31200
3-oxoacyl-[acyl-carrier-protein] reductase (in reverse):
a 3-oxoacyl-[acyl-carrier protein] + NADPH + H+→a (3R)-3-hydroxyacyl-[acyl-carrier protein] + NADP+
(EC 1.1.1.100)
RR42_RS04765
RR42_RS08710
RR42_RS09330
RR42_RS10255
RR42_RS10315
RR42_RS10320
RR42_RS11070
RR42_RS11550
RR42_RS13675
RR42_RS13690
RR42_RS14100
RR42_RS16365
RR42_RS16375
RR42_RS16800
RR42_RS17660
RR42_RS21765
RR42_RS21790
RR42_RS21865
RR42_RS22390
RR42_RS22710
RR42_RS22740
RR42_RS22810
RR42_RS23420
RR42_RS23690
RR42_RS24195
RR42_RS25125
RR42_RS25495
RR42_RS28045
RR42_RS28985
RR42_RS29305
RR42_RS31190
RR42_RS31670
RR42_RS31820
RR42_RS31835
RR42_RS31900
RR42_RS33070
RR42_RS33710
RR42_RS34680
RR42_RS35910
RR42_RS36415
3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase:
a (3R)-3-hydroxyacyl-[acyl-carrier protein]→a trans-2-enoyl-[acyl-carrier protein] + H2O
(EC 4.2.1.59)
RR42_RS11820
3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase:
a (3R)-3-hydroxydecanoyl-[acp]→a (2E)-dec-2-enoyl-[acp] + H2O
(EC 4.2.1.59)
RR42_RS11820
Trans-2-decenoyl-[acyl-carrier-protein] isomerase:
a (2E)-dec-2-enoyl-[acp]→a (3Z)-dec-3-enoyl-[acp]
(EC 5.3.3.14)
No genes
Enoyl-[acyl-carrier-protein] reductase (NADH) (in reverse):
a trans-2-enoyl-[acyl-carrier protein] + NADH + H+→a 2,3,4-saturated fatty acyl-[acp] + NAD+
(EC 1.3.1.9)
RR42_RS03815
RR42_RS10070
RR42_RS10225
RR42_RS13390
RR42_RS25240
RR42_RS31520
RR42_RS31940
RR42_RS36330
Enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) (in reverse):
a trans-2-enoyl-[acyl-carrier protein] + NADPH + H+→a 2,3,4-saturated fatty acyl-[acp] + NADP+
(EC 1.3.1.10; 1.3.1.104; 1.3.1.39)
RR42_RS13390
RR42_RS36330
Beta-ketoacyl-acyl-carrier-protein synthase II:
a 2,3,4-saturated fatty acyl-[acp] + a malonyl-[acp] + H+→a 3-oxoacyl-[acyl-carrier protein] + a soluble [acyl-carrier protein] + CO2
(EC 2.3.1.179; 2.3.1.41)
RR42_RS14090
RR42_RS31185
RR42_RS31200
Beta-ketoacyl-acyl-carrier-protein synthase II:
a (3Z)-dec-3-enoyl-[acp] + a malonyl-[acp] + H+→a (5Z)-3-oxododec-5-enoyl-[acp] + a soluble [acyl-carrier protein] + CO2
(EC 2.3.1.179; 2.3.1.41)
RR42_RS14090
RR42_RS31185
RR42_RS31200
3-oxoacyl-[acyl-carrier-protein] reductase (in reverse):
a (5Z)-3-oxododec-5-enoyl-[acp] + NADPH + H+→a (3R,5Z)-3-hydroxydodec-5-enoyl-[acp] + NADP+
(EC 1.1.1.100)
RR42_RS04765
RR42_RS08710
RR42_RS09330
RR42_RS10255
RR42_RS10315
RR42_RS10320
RR42_RS11070
RR42_RS11550
RR42_RS13675
RR42_RS13690
RR42_RS14100
RR42_RS16365
RR42_RS16375
RR42_RS16800
RR42_RS17660
RR42_RS21765
RR42_RS21790
RR42_RS21865
RR42_RS22390
RR42_RS22710
RR42_RS22740
RR42_RS22810
RR42_RS23420
RR42_RS23690
RR42_RS24195
RR42_RS25125
RR42_RS25495
RR42_RS28045
RR42_RS28985
RR42_RS29305
RR42_RS31190
RR42_RS31670
RR42_RS31820
RR42_RS31835
RR42_RS31900
RR42_RS33070
RR42_RS33710
RR42_RS34680
RR42_RS35910
RR42_RS36415
3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase:
a (3R,5Z)-3-hydroxydodec-5-enoyl-[acp]→a (2E,5Z)-dodeca-3,5-dienoyl-[acp] + H2O
(EC 4.2.1.59)
RR42_RS11820
Enoyl-[acyl-carrier-protein] reductase (NADH) (in reverse):
a (2E,5Z)-dodeca-3,5-dienoyl-[acp] + NADH + H+→a (5Z)-dodec-5-enoyl-[acp] + NAD+
(EC 1.3.1.9)
RR42_RS03815
RR42_RS10070
RR42_RS10225
RR42_RS13390
RR42_RS25240
RR42_RS31520
RR42_RS31940
RR42_RS36330

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information