MetaCyc Pathway: lipoate biosynthesis and incorporation V (mammals) in Cupriavidus basilensis FW507-4G11

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Lipoyl(octanoyl) transferase:
an octanoyl-[acp] + [glycine cleavage system lipoyl-carrier protein]-L-lysine→a [glycine-cleavage complex H protein] N6-octanoyl-L-lysine + a soluble [acyl-carrier protein] + H+ (EC 2.3.1.181)
RR42_RS00630
Lipoyl synthase:
a [glycine-cleavage complex H protein] N6-octanoyl-L-lysine + 2 a reduced [2Fe-2S] ferredoxin + 2 S-adenosyl-L-methionine + 2 a sulfurated [sulfur carrier]→a [glycine-cleavage complex H protein] N6-[(R)-lipoyl]-L-lysine + 2 5'-deoxyadenosine + 2 L-methionine + 2 an oxidized [2Fe-2S] ferredoxin + 2 an unsulfurated [sulfur carrier] (EC 2.8.1.8)
RR42_RS00635
a [glycine-cleavage complex H protein] N6-[(R)-lipoyl]-L-lysine + a [lipoyl-carrier protein]-L-lysine→a [lipoyl-carrier protein]-N6-[(R)-lipoyl]-L-lysine + [glycine cleavage system lipoyl-carrier protein]-L-lysine (EC 2.3.1.200)
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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information