MetaCyc Pathway: corallopyronin A biosynthesis in Cupriavidus basilensis FW507-4G11

Add experiment(s):


hydrogen carbonate + S-adenosyl-L-methionine→methyl carbonate + S-adenosyl-L-homocysteine
No genes
malonyl-CoA + a holo [CorK polyketide synthase] + H+→[CorK polyketide synthase] intermediate I + CO2 + coenzyme A
No genes
[Acyl-carrier-protein] S-malonyltransferase:
malonyl-CoA + a holo [CorC acyl-carrier protein]→malonyl-[CorC acyl-carrier protein] + coenzyme A (EC 2.3.1.39)
RR42_RS02935
RR42_RS14105
Alanine--tRNA ligase:
glycine + ATP→(glycyl)adenylate + diphosphate (EC 6.1.1.7; 6.2.1.66)
RR42_RS15150
methyl carbonate + a [CorI non-ribosomal peptide synthase/polyketide synthase hybrid protein]→[CorI NRPS/PKS] intermediate I + H2O
No genes
(glycyl)adenylate + a [CorI non-ribosomal peptide synthase/polyketide synthase hybrid protein]→glycyl-[CorI NRPS/PKS] + AMP (EC 6.2.1.66)
No genes
[CorK polyketide synthase] intermediate I + malonyl-CoA + NADPH + 2 H+→[CorK polyketide synthase] intermediate II + CO2 + coenzyme A + NADP+ + H2O
No genes
malonyl-[CorC acyl-carrier protein] + H+→acetyl-[CorC acyl-carrier protein] + CO2 (EC 4.1.1.aj)
No genes
glycyl-[CorI NRPS/PKS] + [CorI NRPS/PKS] intermediate I→[CorI NRPS/PKS] intermediate II + a [CorI non-ribosomal peptide synthase/polyketide synthase hybrid protein] + H+
No genes
[CorK polyketide synthase] intermediate II + malonyl-CoA + 2 NADPH + 3 H+→[CorK polyketide synthase] intermediate III + CO2 + coenzyme A + 2 NADP+ + H2O
No genes
malonyl-CoA + [CorI NRPS/PKS] intermediate II + NADPH + 2 H+→[CorI NRPS/PKS] intermediate III + CO2 + coenzyme A + NADP+ + H2O
No genes
[CorK polyketide synthase] intermediate III + malonyl-CoA + H+→[CorK polyketide synthase] intermediate IV + CO2 + coenzyme A
No genes
[CorI NRPS/PKS] intermediate III + a holo [CorJ polyketide synthase]→[CorJ polyketide synthase] intermediate I + a [CorI non-ribosomal peptide synthase/polyketide synthase hybrid protein]
No genes
acetyl-[CorC acyl-carrier protein] + [CorK polyketide synthase] intermediate IV + H2O→[CorK polyketide synthase] intermediate V + a holo [CorC acyl-carrier protein] + H+ (EC 2.3.3.g)
No genes
[CorJ polyketide synthase] intermediate I + malonyl-CoA + 2 NADPH + 2 H+ + S-adenosyl-L-methionine→[CorJ polyketide synthase] intermediate II + S-adenosyl-L-homocysteine + CO2 + coenzyme A + 2 NADP+ + H2O
No genes
[CorK polyketide synthase] intermediate V→[CorK polyketide synthase] intermediate VI + H2O (EC 4.2.1.ca)
No genes
[CorJ polyketide synthase] intermediate II + malonyl-CoA + H+→[CorJ polyketide synthase] intermediate III + CO2 + coenzyme A
No genes
[CorK polyketide synthase] intermediate VI + H+→[CorK polyketide synthase] intermediate VII + CO2 (EC 4.1.1.ai)
No genes
[CorK polyketide synthase] intermediate VII + malonyl-CoA + holo [CorL polyketide synthase] + NADPH + 2 H+→[CorL polyketide synthase] intermediate I + CO2 + coenzyme A + a holo [CorK polyketide synthase] + NADP+
No genes
[CorL polyketide synthase] intermediate I→[CorL polyketide synthase] intermediate II + H2O
No genes
[CorL polyketide synthase] intermediate II + NADPH + H+→[CorL polyketide synthase] intermediate III + NADP+
No genes
[CorL polyketide synthase] intermediate III + malonyl-CoA + H+→[CorL polyketide synthase]-intermediate IV + CO2 + coenzyme A
No genes
acetyl-[CorC acyl-carrier protein] + [CorL polyketide synthase]-intermediate IV + H2O→[CorL polyketide synthase] intermediate V + a holo [CorC acyl-carrier protein] + H+ (EC 2.3.3.g)
No genes
[CorL polyketide synthase] intermediate V→[CorL polyketide synthase] intermediate VI + H2O (EC 4.2.1.ca)
No genes
[CorL polyketide synthase] intermediate VI + H+→[CorL polyketide synthase] intermediate VII + CO2 (EC 4.1.1.ai)
No genes
[CorL polyketide synthase] intermediate VII + malonyl-CoA + NADPH + H+ + S-adenosyl-L-methionine→[CorL polyketide synthase] intermediate VIII + S-adenosyl-L-homocysteine + CO2 + coenzyme A + NADP+ + H2O
No genes
[CorL polyketide synthase] intermediate VIII + malonyl-CoA + H+→[CorL polyketide synthase] intermediate IX + CO2 + coenzyme A
No genes
[CorJ polyketide synthase] intermediate III + [CorL polyketide synthase] intermediate IX→[CorL polyketide synthase] intermediate X + a holo [CorJ polyketide synthase]
No genes
[CorL polyketide synthase] intermediate X→pre-corallopyronin A + holo [CorL polyketide synthase]
No genes
pre-corallopyronin A + dioxygen + 2 H+ + 2 a reduced ferredoxin [iron-sulfur] cluster→corallopyronin A + 2 an oxidized ferredoxin [iron-sulfur] cluster + H2O
No genes

Links:

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information