Phospholipase A(2):
a [glycerolipid]-arachidonate + H2O→arachidonate + a glycerolipid + H+ (EC 3.1.1.4) |
| No genes |
Arachidonate 12-lipoxygenase:
arachidonate + dioxygen→(12S)-HpETE (EC 1.13.11.31) |
| No genes |
Arachidonate 15-lipoxygenase:
arachidonate + dioxygen→(15S)-HpETE (EC 1.13.11.33) |
| No genes |
Arachidonate 5-lipoxygenase:
arachidonate + dioxygen→(5S)-HpETE (EC 1.13.11.34) |
| No genes |
Arachidonate 8-lipoxygenase:
arachidonate + dioxygen→(8S)-HpETE (EC 1.13.11.40) |
| No genes |
Prostaglandin-endoperoxide synthase:
arachidonate + a reduced two electron carrier + 2 dioxygen→prostaglandin H2 + an oxidized electron carrier + H2O (EC 1.14.99.1) |
| No genes |
| arachidonate + dioxygen + a reduced [NADPH-hemoprotein reductase]→5,6-EET + an oxidized [NADPH-hemoprotein reductase] + H2O (EC 1.14.14.M19) |
| No genes |
| arachidonate + dioxygen + a reduced [NADPH-hemoprotein reductase]→8,9-EET + an oxidized [NADPH-hemoprotein reductase] + H2O (EC 1.14.14.M19) |
| No genes |
| arachidonate + dioxygen + a reduced [NADPH-hemoprotein reductase]→11,12-EET + an oxidized [NADPH-hemoprotein reductase] + H2O (EC 1.14.14.M19) |
| No genes |
| arachidonate + dioxygen + a reduced [NADPH-hemoprotein reductase]→14,15-EET + an oxidized [NADPH-hemoprotein reductase] + H2O (EC 1.14.14.M19) |
| No genes |
| arachidonate + dioxygen + a reduced [NADPH-hemoprotein reductase]→20-hydroxyarachidonate + an oxidized [NADPH-hemoprotein reductase] + H2O |
| No genes |
| arachidonate + dioxygen→(15R)-HpETE |
| No genes |
| arachidonate + dioxygen + H2O→8-epi-prostaglandin F2α (spontaneous) |
| No genes |
| arachidonate + dioxygen + H2O→5-iso prostaglandin F2α-VI (spontaneous) |
| No genes |
| arachidonate + dioxygen + H2O→11-HETE + hydrogen peroxide |
| No genes |
| arachidonate + dioxygen + a reduced [NADPH-hemoprotein reductase]→9-HETE + an oxidized [NADPH-hemoprotein reductase] + H2O |
| No genes |
Prostaglandin-D synthase:
prostaglandin H2→prostaglandin D2 (EC 5.3.99.2) |
| No genes |
Prostaglandin-E synthase:
prostaglandin H2→prostaglandin E2 (EC 5.3.99.3) |
| No genes |
Prostaglandin-I synthase:
prostaglandin H2→prostaglandin I2 (EC 5.3.99.4) |
| No genes |
| prostaglandin H2 + a reduced thioredoxin→prostaglandin F2α + an oxidized thioredoxin (EC 1.11.1.20) |
| No genes |
| (12S)-HpETE→hepoxilin A3 (EC 5.4.4.7) |
| No genes |
Phospholipid-hydroperoxide glutathione peroxidase:
(12S)-HpETE + 2 glutathione→12(S)-HETE + glutathione disulfide + H2O (EC 1.11.1.12) |
| No genes |
Phospholipid-hydroperoxide glutathione peroxidase:
(5S)-HpETE + 2 glutathione→5(S)-HETE + glutathione disulfide + H2O (EC 1.11.1.12) |
| No genes |
Phospholipid-hydroperoxide glutathione peroxidase:
(15R)-HpETE + 2 glutathione→15(R)-HETE + glutathione disulfide + H2O (EC 1.11.1.12) |
| No genes |
Thromboxane-A synthase:
prostaglandin H2→12S-HHTrE + malondialdehyde (EC 5.3.99.5) |
| No genes |
Soluble epoxide hydrolase:
5,6-EET + H2O→5,6-DiHETrE (EC 3.3.2.10) |
| No genes |
Soluble epoxide hydrolase:
8,9-EET + H2O→8,9-DiHETrE (EC 3.3.2.10) |
| No genes |
Soluble epoxide hydrolase:
11,12-EET + H2O→11,12-DiHETrE (EC 3.3.2.10) |
| No genes |
Soluble epoxide hydrolase:
14,15-EET + H2O→14,15-DiHETrE (EC 3.3.2.10) |
| No genes |
| (15S)-HpETE + L-cysteine + H+→eoxin E4 + H2O |
| No genes |
Phospholipid-hydroperoxide glutathione peroxidase:
(8S)-HpETE + 2 glutathione→8(S)-HETE + glutathione disulfide + H2O (EC 1.11.1.12) |
| No genes |
Arachidonate 5-lipoxygenase:
(5S)-HpETE→leukotriene A4 + H2O (EC 1.13.11.34) |
| No genes |
Phospholipid-hydroperoxide glutathione peroxidase:
(15S)-HpETE + 2 glutathione→15(S)-HETE + glutathione disulfide + H2O (EC 1.11.1.12) |
| No genes |
Thromboxane-A synthase:
prostaglandin H2→thromboxane A2 (EC 5.3.99.5) |
| No genes |
15-hydroxyprostaglandin dehydrogenase (NAD(+)):
prostaglandin E2 + NAD+→15-dehydro-prostaglandin E2 + NADH + H+ (EC 1.1.1.141) |
| No genes |
15-hydroxyicosatetraenoate dehydrogenase:
15(S)-HETE + NAD(P)+→15-oxo-ETE + NAD(P)H + H+ (EC 1.1.1.232) |
| No genes |
Leukotriene-A(4) hydrolase:
leukotriene A4 + H2O→leukotriene B4 (EC 3.3.2.6) |
| No genes |
Leukotriene-C(4) synthase (in reverse):
leukotriene A4 + glutathione→leukotriene C4 (EC 4.4.1.20) |
| No genes |
15-hydroxyprostaglandin dehydrogenase (NAD(+)):
prostaglandin F2α + NAD+→15-dehydro-prostaglandin F2α + NADH + H+ (EC 1.1.1.141) |
| No genes |
| prostaglandin E2→prostaglandin A2 + H2O |
| No genes |
| 5(S)-HETE + NADP+→5-oxo-ETE + NADPH + H+ (EC 1.1.1.M76) |
| No genes |
| 15(R)-HETE + dioxygen→15 epi-lipoxin A4 |
| No genes |
| prostaglandin I2 + H2O→6-oxoprostaglandin F1α |
| No genes |
| prostaglandin D2→2,3-dinor-11-epi-prostaglandin F2α |
| No genes |
| prostaglandin D2→15-dehydro-13,14-dihydro-prostaglandin D2 |
| No genes |
| prostaglandin D2 + NADPH + H+→11-epi-prostaglandin F2α + NADP+ |
| No genes |
| prostaglandin F2α→2,3,4,5-tetranor-prostaglandin FM |
| No genes |
| prostaglandin D2→prostaglandin J2 + H2O |
| No genes |
| prostaglandin D2 + NADP+→prostaglandin K2 + NADPH + H+ |
| No genes |
| prostaglandin E2 + NADP+→prostaglandin K2 + NADPH + H+ |
| No genes |
| prostaglandin E2→11-epi-prostaglandin E2 |
| No genes |
| prostaglandin E2 + dioxygen + a reduced [NADPH-hemoprotein reductase]→20-hydroxyprostaglandin E2 + an oxidized [NADPH-hemoprotein reductase] + H2O |
| No genes |
| prostaglandin E2→tetranor-PGEM |
| No genes |
| thromboxane A2 + H2O→thromboxane B2 |
| No genes |
Arachidonate 15-lipoxygenase:
15(S)-HETE + dioxygen→lipoxin A4 (EC 1.13.11.33) |
| No genes |
| 15(S)-HETE + a reduced two electron carrier + dioxygen→8,15-diHETE + an oxidized electron carrier + H2O |
| No genes |
| 12(S)-HETE + NADP+→12-oxo-ETE + NADPH + H+ |
| No genes |
| 5(S)-HETE + a reduced two electron carrier + dioxygen→5(S),15(S)-diHETE + an oxidized electron carrier + H2O |
| No genes |
| leukotriene A4 + H2O→6-trans-leukotriene B4 |
| No genes |
15-oxoprostaglandin 13-oxidase (in reverse):
15-dehydro-prostaglandin E2 + NAD(P)H + H+→15-dehydro-13,14-dihydro-prostaglandin E2 + NAD(P)+ (EC 1.3.1.48) |
| No genes |
| leukotriene B4 + dioxygen + a reduced [NADPH-hemoprotein reductase]→20-hydroxy-leukotriene B4 + an oxidized [NADPH-hemoprotein reductase] + H2O (EC 1.14.14.94) |
| No genes |
| leukotriene C4 + H2O→leukotriene D4 + L-glutamate (EC 3.4.19.14) |
| No genes |
15-oxoprostaglandin 13-oxidase (in reverse):
15-dehydro-prostaglandin F2α + NADPH + H+→15-dehydro-13,14-dihydro-prostaglandin F2α + NADP+ (EC 1.3.1.48) |
| No genes |
| 6-oxoprostaglandin F1α + NADP+→6-oxo-prostaglandin E1 + NADPH + H+ |
| No genes |
| 11-epi-prostaglandin F2α→15-dehydro-13,14-dihydro-prostaglandin F2α |
| No genes |
| prostaglandin J2→Δ12,14-prostaglandin J2 |
| No genes |
| prostaglandin A2→prostaglandin B2 |
| No genes |
| 15-dehydro-13,14-dihydro-prostaglandin F2α + a reduced two electron carrier→13,14-dihydro-prostaglandin F2α + an oxidized electron carrier |
| No genes |
| Δ12,14-prostaglandin J2→15-deoxy-Δ12,14-prostaglandin J2 + H2O |
| No genes |
| 15-dehydro-13,14-dihydro-prostaglandin E2→bicyclo prostaglandin E2 + H2O |
| No genes |
| leukotriene D4→11-trans-leukotriene D4 |
| No genes |
| 20-hydroxy-leukotriene B4 + 2 dioxygen + 2 a reduced [NADPH-hemoprotein reductase]→20-carboxy-leukotriene B4 + 2 an oxidized [NADPH-hemoprotein reductase] + H+ + 3 H2O (EC 1.14.14.94) |
| No genes |
Membrane dipeptidase:
leukotriene D4 + H2O→leukotriene E4 + glycine (EC 3.4.13.19) |
| RR42_RS22235 |
| leukotriene E4→11-trans leukotriene E4 |
| No genes |