MetaCyc Pathway: myxochelin A and B biosynthesis in Cupriavidus basilensis FW507-4G11

Add experiment(s):


2,3-dihydroxybenzoate + ATP + H+→(2,3-dihydroxybenzoyl)adenylate + diphosphate (EC 6.2.1.71)
No genes
Lysine--tRNA ligase:
L-lysine + ATP + H+→(L-lysyl)adenylate + diphosphate
(EC 6.1.1.6; 6.2.1.an)
RR42_RS06070
(L-lysyl)adenylate + a holo-[MxcG non-ribosomal peptide synthase]→L-lysyl-[MxcG non-ribosomal peptide synthase] + AMP + H+ (EC 6.2.1.an)
No genes
(2,3-dihydroxybenzoyl)adenylate + a holo-[MxcF aryl-carrier protein]→2,3-dihydroxybenzoyl-[MxcF aryl-carrier protein] + AMP + H+ (EC 6.2.1.71)
No genes
2,3-dihydroxybenzoyl-[MxcF aryl-carrier protein] + L-lysyl-[MxcG non-ribosomal peptide synthase]→N6-(2,3-dihydsroxybenzoyl)-L-lysyl-[MxcG non-ribosomal peptide synthase] + a holo-[MxcF aryl-carrier protein] + H+
No genes
2,3-dihydroxybenzoyl-[MxcF aryl-carrier protein] + N6-(2,3-dihydsroxybenzoyl)-L-lysyl-[MxcG non-ribosomal peptide synthase]→N1,N6-(di-2,3-dihydroxybenzoyl)-L-lysyl-[MxcG non-ribosomal peptide synthase] + a holo-[MxcF aryl-carrier protein] + H+
No genes
N1,N6-(di-2,3-dihydroxybenzoyl)-L-lysyl-[MxcG non-ribosomal peptide synthase] + NADPH + H+→myxochelin aldehyde intermediate + a holo-[MxcG non-ribosomal peptide synthase] + NADP+
No genes
myxochelin aldehyde intermediate + NADPH + H+→myxochelin A + NADP+
No genes
myxochelin aldehyde intermediate + L-glutamate→myxochelin B + 2-oxoglutarate + H+
No genes

Links:

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information