MetaCyc Pathway: diazepinomicin biosynthesis in Cupriavidus basilensis FW507-4G11

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3-amino-5-hydroxybenzoate + NADH + dioxygen + 2 H+→5-aminobenzene-1,3-diol + CO2 + NAD+ + H2O
No genes
2-amino-4-deoxychorismate synthase (in reverse):
chorismate + L-glutamine→(2S)-2-amino-4-deoxy-chorismate + L-glutamate
(EC 2.6.1.86)
No genes
5-aminobenzene-1,3-diol + NADPH + dioxygen + H+→6-aminobenzene-1,2,4-triol + NADP+ + H2O
No genes
(2S)-2-amino-4-deoxy-chorismate + H2O→(5S,6S)-6-amino-5-hydroxycyclohexa-1,3-diene-1-carboxylate + pyruvate (EC 3.3.2.15)
No genes
6-aminobenzene-1,2,4-triol + dioxygen + H+ + 2 a reduced ferredoxin [iron-sulfur] cluster→2-amino-6-hydroxy-1,4-benzoquinone + 2 an oxidized ferredoxin [iron-sulfur] cluster + 2 H2O
No genes
(5S,6S)-6-amino-5-hydroxycyclohexa-1,3-diene-1-carboxylate + NAD+→3-hydroxyanthranilate + NADH + 2 H+
RR42_RS31915
3-hydroxyanthranilate + ATP + H+→3-hydroxyanthranilate adenylate + diphosphate
No genes
2-amino-6-hydroxy-1,4-benzoquinone + 3-hydroxyanthranilate adenylate + a reduced two electron carrier→4,6,8-trihydroxydibenzodiazepinone + AMP + an oxidized electron carrier + H2O
No genes
4,6,8-trihydroxydibenzodiazepinone + (2E,6E)-farnesyl diphosphate→diazepinomicin + diphosphate (EC 2.5.1.M31)
No genes

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information