MetaCyc Pathway: sulfazecin biosynthesis in Cupriavidus basilensis FW507-4G11

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Proline--tRNA ligase:
L-alanine + ATP + H+→(L-alanyl)adenylate + diphosphate
(EC 6.1.1.15; 6.1.1.7; 6.2.1.67)
RR42_RS15150
RR42_RS17925
L-serine + ATPO-phospho-L-serine + ADP + H+ (EC 2.7.1.225)
No genes
D-glutamate + ATP + H+→(D-glutamyl)adenylate + diphosphate (EC 6.2.1.M41)
No genes
O-phospho-L-serine + L-glutamateN-[(2S)-2-amino-2-carboxyethyl]-L-glutamate + phosphate (EC 2.5.1.140)
No genes
(D-glutamyl)adenylate + a holo-[D-glutamyl-carrier protein]→a D-glutamyl-[D-glutamyl-carrier protein] + AMP + H+ (EC 6.2.1.M41)
No genes
(L-alanyl)adenylate + a [SulM alanyl-carrier protein domain]→an L-alanyl-[SulM alanyl-carrier protein domain] + AMP + H+ (EC 6.2.1.67)
No genes
N-[(2S)-2-amino-2-carboxyethyl]-L-glutamate + NAD+ + H2O→L-2,3-diaminopropanoate + 2-oxoglutarate + NADH + H+ (EC 1.5.1.51)
No genes
an L-alanyl-[SulM alanyl-carrier protein domain]→a D-alanyl-[SulM alanyl-carrier protein domain]
No genes
a D-alanyl-[SulM alanyl-carrier protein domain] + a D-glutamyl-[D-glutamyl-carrier protein]→a D-glutamyl-γ-D-alanyl-[SulM alanyl-carrier protein domain] + a holo-[D-glutamyl-carrier protein] + H+
No genes
L-2,3-diaminopropanoate + ATP + H+→(L-2,3-diaminopropanoatel)adenylate + diphosphate (EC 6.2.1.M42)
No genes
(L-2,3-diaminopropanoatel)adenylate + a [SulM L-2,3-diaminopropanoate-carrier protein domain]→a L-2,3-diaminopropanoyl-[SulM L-2,3-diaminopropanoate-carrier protein domain] + AMP + H+ (EC 6.2.1.M42)
No genes
a L-2,3-diaminopropanoyl-[SulM L-2,3-diaminopropanoate-carrier protein domain] + a D-glutamyl-γ-D-alanyl-[SulM alanyl-carrier protein domain]→a D-glutamyl-γ-D-alanyl-L-2,3-diaminopropanoyl-[SulM L-2,3-diaminopropanoate-carrier protein domain] + H+ + a [SulM alanyl-carrier protein domain]
No genes
a D-glutamyl-γ-D-alanyl-L-2,3-diaminopropanoyl-[SulM L-2,3-diaminopropanoate-carrier protein domain] + 3'-phosphoadenylyl-sulfate→a D-glutamyl-γ-D-alanyl-N-sulfo-L-2,3-diaminopropanoyl-[SulM L-2,3-diaminopropanoate-carrier protein domain] + adenosine 3',5'-bisphosphate + 2 H+ (EC 2.8.2.M5)
No genes
a D-glutamyl-γ-D-alanyl-N-sulfo-L-2,3-diaminopropanoyl-[SulM L-2,3-diaminopropanoate-carrier protein domain]→demethoxysulfazecin + a [SulM L-2,3-diaminopropanoate-carrier protein domain]
No genes
demethoxysulfazecin + 2-oxoglutarate + dioxygen→demethylsulfazecin + CO2 + succinate (EC 1.14.11.M37)
No genes
demethylsulfazecin + S-adenosyl-L-methionine→sulfazecin + S-adenosyl-L-homocysteine + H+ (EC 2.1.1.M98)
No genes

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information