Phospholipase A(2):
a [glycerolipid]-(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + H2O→(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + a glycerolipid + H+ (EC 3.1.1.4) |
| No genes |
Arachidonate 12-lipoxygenase:
(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + dioxygen→(14S)-HpDHA (EC 1.13.11.31) |
| No genes |
Arachidonate 15-lipoxygenase:
(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + dioxygen→(17S)-HpDHA (EC 1.13.11.33) |
| No genes |
Phospholipid-hydroperoxide glutathione peroxidase:
(17S)-HpDHA + 2 glutathione→17(S)-HDoHE + glutathione disulfide + H2O (EC 1.11.1.12) |
| No genes |
Arachidonate 15-lipoxygenase:
(17S)-HpDHA→(16S,17S)-epoxy-protectin + H2O (EC 1.13.11.33) |
| No genes |
Arachidonate 12-lipoxygenase:
(14S)-HpDHA→(13S,14S)-epoxy-maresin + H2O (EC 1.13.11.31) |
| No genes |
Leukotriene-C(4) synthase (in reverse):
(13S,14S)-epoxy-maresin + glutathione→MCTR1 (EC 4.4.1.20) |
| No genes |
Leukotriene-C(4) synthase (in reverse):
(16S,17S)-epoxy-protectin + glutathione→PCTR1 (EC 4.4.1.20) |
| No genes |
Arachidonate 5-lipoxygenase:
17(S)-HDoHE + dioxygen→(7S,17S)-17-hydroxy-7-hydroperoxydocosahexaenoate (EC 1.13.11.34) |
| No genes |
Gamma-glutamyltransferase:
PCTR1 + a proteinogenic amino acid→PCTR2 + an α-(γ-L-glutamyl)-L-amino acid (EC 2.3.2.2) |
| RR42_RS05040 |
| RR42_RS15195 |
| RR42_RS23025 |
| RR42_RS26175 |
| RR42_RS27305 |
| RR42_RS32275 |
Gamma-glutamyltransferase:
MCTR1 + a proteinogenic amino acid→MCTR2 + an α-(γ-L-glutamyl)-L-amino acid (EC 2.3.2.2) |
| RR42_RS05040 |
| RR42_RS15195 |
| RR42_RS23025 |
| RR42_RS26175 |
| RR42_RS27305 |
| RR42_RS32275 |
Arachidonate 5-lipoxygenase:
(7S,17S)-17-hydroxy-7-hydroperoxydocosahexaenoate→(7S,8S)-epoxy-resolvin + H2O (EC 1.13.11.34) |
| No genes |
Membrane dipeptidase:
PCTR2 + H2O→PCTR3 + glycine (EC 3.4.13.19) |
| RR42_RS22235 |
Membrane dipeptidase:
MCTR2 + H2O→MCTR3 + glycine (EC 3.4.13.19) |
| RR42_RS22235 |
Leukotriene-C(4) synthase (in reverse):
(7S,8S)-epoxy-resolvin + glutathione→RCTR1 (EC 4.4.1.20) |
| No genes |
Gamma-glutamyltransferase:
RCTR1 + a proteinogenic amino acid→RCTR2 + an α-(γ-L-glutamyl)-L-amino acid (EC 2.3.2.2) |
| RR42_RS05040 |
| RR42_RS15195 |
| RR42_RS23025 |
| RR42_RS26175 |
| RR42_RS27305 |
| RR42_RS32275 |
Membrane dipeptidase:
RCTR2 + H2O→RCTR3 + glycine (EC 3.4.13.19) |
| RR42_RS22235 |
Links:
Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information