MetaCyc Pathway: lipid A-core biosynthesis (P. gingivalis) in Cupriavidus basilensis FW507-4G11

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Glycerol-3-phosphate cytidylyltransferase:
sn-glycerol 3-phosphate + CTP + H+→(2R)-CDP-glycerol + diphosphate (EC 2.7.7.39)
RR42_RS00710
(2R)-CDP-glycerol + P. gingivalis Kdo2-lipid A (penta-acylated, bis-phosphorylated)→P. gingivalis phosphoglycerol-lipid A (penta-acylated) + CMP + H+
No genes
P. gingivalis phosphoglycerol-lipid A (penta-acylated) + UDP-α-D-allosamine→P. gingivalis allosaminyl-phosphoglycerol-lipid A (penta-acylated) + H+ + UDP
No genes
P. gingivalis allosaminyl-phosphoglycerol-lipid A (penta-acylated) + GDP-α-D-mannose→P. gingivalis α-D-mannosyl-[allosaminyl]-phosphoglycerol-lipid A (penta-acylated) + GDP + H+
No genes
P. gingivalis α-D-mannosyl-[allosaminyl]-phosphoglycerol-lipid A (penta-acylated) + 3 GDP-α-D-mannose→P. gingivalis (α-D-mannosyl)4-[allosaminyl]-phosphoglycerol-lipid A (penta-acylated) + 3 GDP + 3 H+
No genes
P. gingivalis (α-D-mannosyl)4-[allosaminyl]-phosphoglycerol-lipid A (penta-acylated) + 2 a phosphatidylethanolamine→P. gingivalis uncapped core I-lipid A (penta-acylated) + 2 a 1,2-diacyl-sn-glycerol
No genes
P. gingivalis uncapped core I-lipid A (penta-acylated) + 4 GDP-α-D-mannose→P. gingivalis capped core I-lipid A (penta-acylated) + 4 GDP + 4 H+
No genes

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information