MetaCyc Pathway: lipid IVA biosynthesis (P. gingivalis) in Cupriavidus basilensis FW507-4G11

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Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase:
UDP-N-acetyl-α-D-glucosamine + a (3R)-3-hydroxy-13-methyltetradecanoyl-[acp]→UDP-3-O-[(3R)-3-hydroxy-13-methyltetradecanoyl]-N-acetyl-α-D-glucosamine + a soluble [acyl-carrier protein] (EC 2.3.1.129)
RR42_RS11815
Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase:
UDP-N-acetyl-α-D-glucosamine + a (3R)-3-hydroxyhexadecanoyl-[acp]→UDP-3-O-[(3R)-3-hydroxyhexanoyl]-N-acetyl-α-D-glucosamine + a soluble [acyl-carrier protein] (EC 2.3.1.129)
RR42_RS11815
UDP-3-O-[(3R)-3-hydroxy-13-methyltetradecanoyl]-N-acetyl-α-D-glucosamine + H2O→UDP-3-O-[(3R)-3-hydroxy-13-methyltetradecanoyl]-α-D-glucosamine + acetate (EC 3.5.1.108)
RR42_RS18040
UDP-3-O-[(3R)-3-hydroxyhexanoyl]-N-acetyl-α-D-glucosamine + H2O→UDP-3-O-[(3R)-3-hydroxy-hexadecanoyl]-α-D-glucosamine + acetate (EC 3.5.1.108)
RR42_RS18040
UDP-3-O-[(3R)-3-hydroxy-13-methyltetradecanoyl]-α-D-glucosamine + a (3R)-3-hydroxy-15-methylhexanoyl-[acp]→UDP-2-N-[(3R)-3-hydroxy-15-methylhexadecanoyl]-3-O-[(3R)-3-hydroxy-13-methyltetradecanoyl]-α-D-glucosamine + a soluble [acyl-carrier protein] + H+ (EC 2.3.1.191)
RR42_RS11825
UDP-3-O-[(3R)-3-hydroxy-hexadecanoyl]-α-D-glucosamine + a (3R)-3-hydroxy-15-methylhexanoyl-[acp]→UDP-2-N-[(3R)-3-hydroxy-16-methylhexadecanoyl]-3-O-[(3R)-3-hydroxyhexadecanoyl]-α-D-glucosamine + a soluble [acyl-carrier protein] + H+ (EC 2.3.1.191)
RR42_RS11825
UDP-2-N-[(3R)-3-hydroxy-16-methylhexadecanoyl]-3-O-[(3R)-3-hydroxyhexadecanoyl]-α-D-glucosamine + H2O→lipid X (P. gingivalis) + 2 H+ + UMP (EC 3.6.1.54)
RR42_RS05405
RR42_RS06330
Lipid-A-disaccharide synthase:
lipid X (P. gingivalis) + UDP-2-N-[(3R)-3-hydroxy-15-methylhexadecanoyl]-3-O-[(3R)-3-hydroxy-13-methyltetradecanoyl]-α-D-glucosamine→lipid A disaccharide (P. gingivalis) + H+ + UDP (EC 2.4.1.182)
RR42_RS11810
Tetraacyldisaccharide 4'-kinase:
lipid A disaccharide (P. gingivalis) + ATP→lipid IVA (P. gingivalis) + ADP + H+ (EC 2.7.1.130)
RR42_RS03460

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information