MetaCyc Pathway: 11-oxyandrogens biosynthesis in Cupriavidus basilensis FW507-4G11

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pregnenolone + dioxygen + a reduced [NADPH-hemoprotein reductase]→17-α-hydroxypregnenolone + an oxidized [NADPH-hemoprotein reductase] + H2O (EC 1.14.14.19)
No genes
17-α-hydroxypregnenolone + dioxygen + a reduced [NADPH-hemoprotein reductase]→3-β-hydroxyandrost-5-en-17-one + acetate + an oxidized [NADPH-hemoprotein reductase] + H+ + H2O (EC 1.14.14.32)
No genes
Testosterone 17-beta-dehydrogenase (NADP(+)) (in reverse):
3-β-hydroxyandrost-5-en-17-one + NADPH + H+→androstenediol + NADP+ (EC 1.1.1.64)
No genes
3-beta-hydroxy-Delta(5)-steroid dehydrogenase:
3-β-hydroxyandrost-5-en-17-one + NAD+→androst-5-ene-3,17-dione + NADH + H+ (EC 1.1.1.145)
No genes
3-beta-hydroxy-Delta(5)-steroid dehydrogenase:
androstenediol + NAD+→17β-hydroxyandrost-5-en-3-one + NADH + H+ (EC 1.1.1.145)
No genes
Steroid Delta-isomerase:
androst-5-ene-3,17-dione→androstenedione (EC 5.3.3.1)
RR42_RS31815
Testosterone 17-beta-dehydrogenase (NADP(+)) (in reverse):
androstenedione + NADPH + H+→testosterone + NADP+ (EC 1.1.1.64)
No genes
Steroid 11-beta-monooxygenase:
androstenedione + dioxygen + 2 H+ + 2 a reduced adrenodoxin→11β-hydroxyandrostenedione + 2 an oxidized adrenodoxin + H2O (EC 1.14.15.4)
No genes
Steroid Delta-isomerase:
17β-hydroxyandrost-5-en-3-one→testosterone (EC 5.3.3.1)
RR42_RS31815
Steroid 11-beta-monooxygenase:
testosterone + dioxygen + 2 H+ + 2 a reduced adrenodoxin→11β-hydroxytestosterone + 2 an oxidized adrenodoxin + H2O (EC 1.14.15.4)
No genes
11-beta-hydroxysteroid dehydrogenase:
11β-hydroxyandrostenedione + NADP+→11-oxoandrostenedione + NADPH + H+ (EC 1.1.1.146)
No genes
Cholestenone 5-alpha-reductase (in reverse):
11β-hydroxyandrostenedione + NADPH + H+→11β-hydroxy-5α-androstanedione + NADP+ (EC 1.3.1.22)
No genes
11-beta-hydroxysteroid dehydrogenase:
11β-hydroxytestosterone + NADP+→11-oxotestosterone + NADPH + H+ (EC 1.1.1.146)
No genes
Testosterone 17-beta-dehydrogenase (NADP(+)) (in reverse):
11-oxoandrostenedione + NADPH + H+→11-oxotestosterone + NADP+ (EC 1.1.1.64)
No genes
Cholestenone 5-alpha-reductase (in reverse):
11-oxoandrostenedione + NADPH + H+→11-oxo-5α-androstanedione + NADP+ (EC 1.3.1.22)
No genes
11-beta-hydroxysteroid dehydrogenase:
11β-hydroxy-5α-androstanedione + NADP+→11-oxo-5α-androstanedione + NADPH + H+ (EC 1.1.1.146)
No genes
Cholestenone 5-alpha-reductase (in reverse):
11β-hydroxytestosterone + NADPH + H+→11β-hydroxydihydrotestosterone + NADP+ (EC 1.3.1.22)
No genes
Cholestenone 5-alpha-reductase (in reverse):
11-oxotestosterone + NADPH + H+→11-oxodihydrotestosterone + NADP+ (EC 1.3.1.22)
No genes
Testosterone 17-beta-dehydrogenase (NADP(+)) (in reverse):
11-oxo-5α-androstanedione + NADPH + H+→11-oxodihydrotestosterone + NADP+ (EC 1.1.1.64)
No genes
11-beta-hydroxysteroid dehydrogenase:
11β-hydroxydihydrotestosterone + NADP+→11-oxodihydrotestosterone + NADPH + H+ (EC 1.1.1.146)
No genes

Links:

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information