MetaCyc Pathway: backdoor pathway of androgen biosynthesis in Cupriavidus basilensis FW507-4G11

Add experiment(s):


pregnenolone + dioxygen + a reduced [NADPH-hemoprotein reductase]→17-α-hydroxypregnenolone + an oxidized [NADPH-hemoprotein reductase] + H2O (EC 1.14.14.19)
No genes
3-beta-hydroxy-Delta(5)-steroid dehydrogenase:
pregnenolone + NAD+→pregn-5-ene-3,20-dione + NADH + H+ (EC 1.1.1.145)
No genes
3-beta-hydroxy-Delta(5)-steroid dehydrogenase:
17-α-hydroxypregnenolone + NAD+→17α-hydroxypregn-5-ene-3,20-dione + NADH + H+ (EC 1.1.1.145)
No genes
Steroid Delta-isomerase:
pregn-5-ene-3,20-dione→progesterone (EC 5.3.3.1)
RR42_RS31815
Steroid Delta-isomerase:
17α-hydroxypregn-5-ene-3,20-dione→17-α-hydroxyprogesterone (EC 5.3.3.1)
RR42_RS31815
progesterone + dioxygen + a reduced [NADPH-hemoprotein reductase]→17-α-hydroxyprogesterone + an oxidized [NADPH-hemoprotein reductase] + H2O (EC 1.14.14.19)
No genes
Cholestenone 5-alpha-reductase (in reverse):
17-α-hydroxyprogesterone + NADPH + H+→5α-pregnan-17α-3,20-dione-17-ol + NADP+ (EC 1.3.1.22)
No genes
3-alpha-hydroxysteroid dehydrogenase (A-specific) (in reverse):
5α-pregnan-17α-3,20-dione-17-ol + NAD(P)H + H+→17-hydroxybrexanolone + NAD(P)+ (EC 1.1.1.213)
No genes
17-hydroxybrexanolone + dioxygen + a reduced [NADPH-hemoprotein reductase]→androsterone + acetate + an oxidized [NADPH-hemoprotein reductase] + H+ + H2O (EC 1.14.14.32)
No genes
Testosterone 17-beta-dehydrogenase (NADP(+)) (in reverse):
androsterone + NADPH + H+→5-α-androstan-3α,17β-diol + NADP+ (EC 1.1.1.64)
No genes
3-beta-(or 20-alpha)-hydroxysteroid dehydrogenase:
5-α-androstan-3α,17β-diol + NADP+→5α-dihydrotestosterone + NADPH + H+ (EC 1.1.1.210)
No genes

Links:

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information