MetaCyc Pathway: mevalonate pathway IV (archaea) in Cupriavidus basilensis FW507-4G11

Add experiment(s):


Acetyl-CoA C-acyltransferase:
2 acetyl-CoA→acetoacetyl-CoA + coenzyme A (EC 2.3.1.16; 2.3.1.9)
RR42_RS00885
RR42_RS02515
RR42_RS03010
RR42_RS07610
RR42_RS07645
RR42_RS10260
RR42_RS10540
RR42_RS11085
RR42_RS16595
RR42_RS22625
RR42_RS24300
RR42_RS24970
RR42_RS25210
RR42_RS25380
RR42_RS25455
RR42_RS26090
RR42_RS27160
RR42_RS27235
RR42_RS28055
RR42_RS28390
RR42_RS31890
RR42_RS31920
RR42_RS35915
RR42_RS36320
RR42_RS37020
Hydroxymethylglutaryl-CoA synthase:
acetoacetyl-CoA + acetyl-CoA + H2O→(S)-3-hydroxy-3-methylglutaryl-CoA + coenzyme A + H+ (EC 2.3.3.10)
No genes
Hydroxymethylglutaryl-CoA reductase (NADPH) (in reverse):
(S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H+→(R)-mevalonate + coenzyme A + 2 NADP+ (EC 1.1.1.34)
No genes
Mevalonate kinase:
(R)-mevalonate + ATP→(R)-5-phosphomevalonate + ADP + H+ (EC 2.7.1.36)
No genes
(R)-5-phosphomevalonate→trans-anhydromevalonate 5-phosphate + H2O (EC 4.2.1.cb)
No genes
trans-anhydromevalonate 5-phosphate + H+→3-methylbut-3-en-1-yl phosphate + CO2 (EC 4.1.1.ak)
No genes
3-methylbut-3-en-1-yl phosphate + ATP→3-methylbut-3-en-1-yl diphosphate + ADP (EC 2.7.4.26)
No genes
Isopentenyl-diphosphate Delta-isomerase:
3-methylbut-3-en-1-yl diphosphate→prenyl diphosphate (EC 5.3.3.2)
No genes

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information