MetaCyc Pathway: ansatrienin biosynthesis in Cupriavidus basilensis FW507-4G11

Add experiment(s):


Alanine racemase:
L-alanine→D-alanine (EC 5.1.1.1; 5.1.1.10)
RR42_RS12035
3-amino-5-hydroxybenzoate + ATP + a holo acp domain within a [polyketide synthase]→3-amino-5-hydroxybenzoyl-[ansatrienin PKS] + AMP + diphosphate (EC 6.2.1.74)
No genes
D-alanine + ATP + a holo [D-alanyl carrier protein]→a D-alanyl-[D-alanyl carrier protein] + AMP + diphosphate (EC 6.2.1.54)
No genes
3-amino-5-hydroxybenzoyl-[ansatrienin PKS] + 2 (S)-methylmalonyl-CoA + 6 malonyl-CoA + 9 NADPH + 17 H+→nonaketide-[ansatrienin PKS] + 8 CO2 + 8 coenzyme A + 9 NADP+ + 5 H2O (EC 2.3.1.M77)
No genes
nonaketide-[ansatrienin PKS]→protoansatrienin + a holo acp domain within a [polyketide synthase] (EC 2.3.1.M78)
No genes
protoansatrienin + S-adenosyl-L-methionine→3-O-methylprotoansatrienin + S-adenosyl-L-homocysteine + H+ (EC 2.1.1.M52)
No genes
3-O-methylprotoansatrienin + a D-alanyl-[D-alanyl carrier protein]→D-alanyl-3-O-methylprotoansatrienin + a holo [D-alanyl carrier protein] (EC 2.3.2.v)
No genes
D-alanyl-3-O-methylprotoansatrienin + cyclohexane-1-carbonyl-CoA→trienomycin A + coenzyme A + H+ (EC 2.3.1.dp)
No genes
D-alanyl-3-O-methylprotoansatrienin + (2S)-2-methylbutanoyl-CoA→trienomycin B + coenzyme A + H+ (EC 2.3.1.dp)
No genes

Links:

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information