MetaCyc Pathway: pseudomonine biosynthesis in Cupriavidus basilensis FW507-4G11

Add experiment(s):


salicylate + ATP + H+→(salicyl)adenylate + diphosphate (EC 6.2.1.61; 6.2.1.65)
No genes
histamine + NADPH + dioxygen→N-hydroxyhistamine + NADP+ + H2O (EC 1.14.13.M66)
No genes
Threonine--tRNA ligase:
L-threonine + ATP + H+→(L-threonyl)adenylate + diphosphate (EC 6.1.1.3; 6.1.1.9; 6.2.1.70)
RR42_RS06600
RR42_RS15095
(salicyl)adenylate + a [PmsE non-ribosomal peptide synthase]→a salicyl-[PmsE non-ribosomal peptide synthase] + AMP + H+ (EC 6.2.1.61)
No genes
(L-threonyl)adenylate + a [PmsG non-ribosomal peptide synthase]→an L-threonyl-[PmsG non-ribosomal peptide synthase] + AMP + H+ (EC 6.2.1.70)
No genes
a salicyl-[PmsE non-ribosomal peptide synthase] + an L-threonyl-[PmsG non-ribosomal peptide synthase]→a salicyl-N-threonyl-[PmsG non-ribosomal peptide synthase protein] + H+ + a [PmsE non-ribosomal peptide synthase]
No genes
a salicyl-N-threonyl-[PmsG non-ribosomal peptide synthase protein]→a salicylmethyloxazolinyl-[PmsG non-ribosomal peptide synthase] + H2O
No genes
N-hydroxyhistamine + a salicylmethyloxazolinyl-[PmsG non-ribosomal peptide synthase]→pre-pseudomonine + a [PmsG non-ribosomal peptide synthase]
No genes
pre-pseudomonine→pseudomonine (spontaneous)
No genes

Links:

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information