MetaCyc Pathway: cobalamin salvage (eukaryotic) in Cupriavidus basilensis FW507-4G11

Add experiment(s):


Cyanocobalamin reductase (cyanide-eliminating) (in reverse):
2 cyanocob(III)alamin + 2 a [cyanocobalamin reductase CblC] + NADPH + H+→2 cob(II)alamin-[cyanocobalamin reductase CblC] + 2 hydrogen cyanide + NADP+ (EC 1.16.1.6)
No genes
cob(II)alamin-[cyanocobalamin reductase CblC] + a [cobalamin trafficking protein CblD]→cob(II)alamin-[CblC-CblD complex]
No genes
Cob(I)yrinic acid a,c-diamide adenosyltransferase:
cob(II)alamin-[CblC-CblD complex] + a [corrinoid adenosyltransferase]→cob(II)alamin-[corrinoid adenosyltranferase] + a [cyanocobalamin reductase CblC] + a [cobalamin trafficking protein CblD] (EC 2.5.1.17)
RR42_RS16125
RR42_RS17280
cob(II)alamin-[CblC-CblD complex] + an apo-[methionine synthase] + H+→cob(II)alamin-[methionine synthase] + a [cyanocobalamin reductase CblC] + a [cobalamin trafficking protein CblD]
No genes
[Methionine synthase] reductase (in reverse):
2 cob(II)alamin-[methionine synthase] + NADPH + 2 S-adenosyl-L-methionine→2 methylcob(III)alamin-[methionine synthase] + 2 S-adenosyl-L-homocysteine + NADP+ + H+ (EC 1.16.1.8)
No genes
2 cob(II)alamin-[corrinoid adenosyltranferase] + a [reduced flavoprotein]→2 cob(I)alamin-[corrinoid adenosyltranferase] + an [oxidized flavoprotein] + 2 H+ (spontaneous) (EC 2.5.1.154; 2.5.1.17)
RR42_RS16125
RR42_RS17280
Cob(I)yrinic acid a,c-diamide adenosyltransferase:
cob(I)alamin-[corrinoid adenosyltranferase] + ATP + H+→adenosylcob(III)alamin-[corrinoid adenosyltranferase] + triphosphate (EC 2.5.1.17)
RR42_RS16125
RR42_RS17280
Cob(I)yrinic acid a,c-diamide adenosyltransferase:
adenosylcob(III)alamin-[corrinoid adenosyltranferase] + an apo-methylmalonyl-CoA mutase + H+→adenosylcobalamin-[methylmalonyl-CoA mutase] + a [corrinoid adenosyltransferase] (EC 2.5.1.17)
RR42_RS16125
RR42_RS17280

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information