MetaCyc Pathway: adenosylcobinamide-GDP biosynthesis from cobyrinate a,c-diamide in Cupriavidus basilensis FW507-4G11

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Cob(I)yrinic acid a,c-diamide adenosyltransferase:
cob(II)yrinate a,c-diamide + a [corrinoid adenosyltransferase]→cob(II)yrinate a,c-diamide-[corrinoid adenosyltranferase]
(EC 2.5.1.17)
RR42_RS16125
RR42_RS17280
Cob(I)yrinic acid a,c-diamide adenosyltransferase:
2 cob(II)yrinate a,c-diamide-[corrinoid adenosyltranferase] + a [reduced flavoprotein]→2 cob(I)yrinate a,c-diamide-[corrinoid adenosyltranferase] + an [oxidized flavoprotein] + 2 H+
(spontaneous) (EC 2.5.1.17)
RR42_RS16125
RR42_RS17280
Cob(I)yrinic acid a,c-diamide adenosyltransferase:
2 cob(I)yrinate a,c-diamide-[corrinoid adenosyltranferase] + 2 ATP + 2 H+→2 adenosyl-cob(III)yrinate a,c-diamide + 2 a [corrinoid adenosyltransferase] + 2 triphosphate
(EC 2.5.1.17)
RR42_RS16125
RR42_RS17280
Adenosylcobyric acid synthase (glutamine-hydrolyzing):
adenosyl-cob(III)yrinate a,c-diamide + 4 ATP + 4 L-glutamine + 4 H2O→adenosylcobyrate + 4 ADP + 4 L-glutamate + 4 H+ + 4 phosphate
(EC 6.3.5.10)
RR42_RS16075
Adenosylcobinamide-phosphate synthase:
adenosylcobyrate + (R)-1-amino-2-propanol O-2-phosphate + ATP→adenosyl-cobinamide phosphate + ADP + H+ + phosphate
(EC 6.3.1.10)
RR42_RS14790
RR42_RS16085
Adenosylcobinamide-phosphate guanylyltransferase:
adenosyl-cobinamide phosphate + GTP + H+→adenosylcobinamide-GDP + diphosphate
(EC 2.7.7.62)
RR42_RS16080

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information