MetaCyc Pathway: UDP-N-acetylmuramoyl-pentapeptide biosynthesis III (meso-diaminopimelate containing) in Cupriavidus basilensis FW507-4G11

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D-alanine--D-alanine ligase:
2 D-alanine + ATP→D-alanyl-D-alanine + ADP + H+ + phosphate (EC 6.3.2.4)
RR42_RS18065
UDP-N-acetylglucosamine 1-carboxyvinyltransferase:
UDP-N-acetyl-α-D-glucosamine + phosphoenolpyruvate→UDP-N-acetyl-α-D-glucosamine-enolpyruvate + phosphate (EC 2.5.1.7)
RR42_RS18925
RR42_RS22240
UDP-N-acetyl-α-D-glucosamine-enolpyruvate + NADPH + H+→UDP-N-acetyl-α-D-muramate + NADP+ (EC 1.3.1.98)
RR42_RS17160
UDP-N-acetylmuramate--L-alanine ligase:
UDP-N-acetyl-α-D-muramate + L-alanine + ATP→UDP-N-acetyl-α-D-muramoyl-L-alanine + ADP + H+ + phosphate (EC 6.3.2.8)
RR42_RS18070
UDP-N-acetyl-α-D-muramoyl-L-alanine + L-glutamate + ATP→UDP-N-acetyl-α-D-muramoyl-L-alanyl-L-glutamate + ADP + H+ + phosphate (EC 6.3.2.53)
No genes
UDP-N-acetyl-α-D-muramoyl-L-alanyl-L-glutamate + ATP + H2O→UDP-N-acetyl-α-D-muramoyl-L-alanyl-D-glutamate + AMP + diphosphate + H+ (EC 5.1.1.23)
No genes
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase:
UDP-N-acetyl-α-D-muramoyl-L-alanyl-D-glutamate + meso-diaminopimelate + ATP→UDP-MurNAc-L-Ala-γ-D-Glu-meso-DAP + ADP + H+ + phosphate (EC 6.3.2.13)
RR42_RS18100
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase:
D-alanyl-D-alanine + UDP-MurNAc-L-Ala-γ-D-Glu-meso-DAP + ATP→UDP-MurNAc-L-Ala-γ-D-Glu-meso-DAP-D-Ala-D-Ala + ADP + H+ + phosphate (EC 6.3.2.10)
RR42_RS18095

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information