MetaCyc Pathway: psilocybin biosynthesis in Cupriavidus basilensis FW507-4G11

Add experiment(s):


L-tryptophan + H+→tryptamine + CO2 (EC 4.1.1.105; 4.1.1.28)
RR42_RS26695
4-hydroxy-L-tryptophan + H+→4-hydroxytryptamine + CO2 (EC 4.1.1.105)
No genes
tryptamine + dioxygen + a reduced [NADPH-hemoprotein reductase]→4-hydroxytryptamine + an oxidized [NADPH-hemoprotein reductase] + H2O (EC 1.14.99.59)
No genes
4-hydroxytryptamine + ATP→norbaeocystin + ADP + H+ (EC 2.7.1.222)
No genes
norbaeocystin + S-adenosyl-L-methionine→baeocystin + S-adenosyl-L-homocysteine + H+ (EC 2.1.1.345)
No genes
baeocystin + S-adenosyl-L-methionine→psilocybin + S-adenosyl-L-homocysteine + H+ (EC 2.1.1.345)
No genes

Links:

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information