MetaCyc Pathway: spongiadioxin C biosynthesis in Cupriavidus basilensis FW507-4G11

Add experiment(s):


Chorismate lyase:
chorismate→4-hydroxybenzoate + pyruvate
(EC 4.1.3.40)
RR42_RS17665
4-hydroxybenzoate 3-monooxygenase:
4-hydroxybenzoate + NADPH + dioxygen + H+→protocatechuate + NADP+ + H2O
(EC 1.14.13.2)
RR42_RS21940
protocatechuate + bromide + NADPH + dioxygen + 2 H+→3-bromo-4,5-dihydroxybenzoate + NADP+ + 2 H2O (EC 1.14.19.55)
No genes
3-bromo-4,5-dihydroxybenzoate + bromide + NADPH + dioxygen + 3 H+→3,5-dibromocatechol + CO2 + NADP+ + 2 H2O (EC 1.14.19.55)
No genes
3,5-dibromocatechol + 2,4-dibromophenol + dioxygen + 2 H+ + 2 a reduced ferredoxin [iron-sulfur] cluster→2,4-dibromo-6-(2,4-dibromo-6-hydroxyphenoxy)phenol + 2 an oxidized ferredoxin [iron-sulfur] cluster + 2 H2O (EC 1.14.19.M18)
No genes
2,4-dibromophenol + 3,5-dibromocatechol + dioxygen + 2 H+ + 2 a reduced ferredoxin [iron-sulfur] cluster→6,6'-oxybis(2,4-dibromophenol) + 2 an oxidized ferredoxin [iron-sulfur] cluster + 2 H2O (EC 1.14.19.M18)
No genes
2,4-dibromo-6-(2,4-dibromo-6-hydroxyphenoxy)phenol→spongiadioxin C + bromide + H+
No genes

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information