MetaCyc Pathway: pyoluteorin biosynthesis in Cupriavidus basilensis FW507-4G11

Add experiment(s):


Proline--tRNA ligase:
L-proline + ATP + H+→(L-prolyl)adenylate + diphosphate (EC 6.1.1.15; 6.2.1.53)
RR42_RS17925
(L-prolyl)adenylate + a holo-[PltL prolyl-carrier protein]→an L-prolyl-[PltL prolyl-carrier protein] + AMP + H+ (EC 6.2.1.53)
No genes
an L-prolyl-[PltL prolyl-carrier protein] + 2 an oxidized electron-transfer flavoprotein + H+→a 1H-pyrrole-2-carbonyl-[PltL prolyl-carrier protein] + 2 a reduced electron-transfer flavoprotein (EC 1.3.8.14)
No genes
a 1H-pyrrole-2-carbonyl-[PltL prolyl-carrier protein] + chloride + FADH2 + dioxygen→a 5-chloro-1H-pyrrole-2-carbonyl-[PltL prolyl-carrier protein] + FAD + 2 H2O (EC 1.14.19.56)
No genes
a 5-chloro-1H-pyrrole-2-carbonyl-[PltL prolyl-carrier protein] + chloride + FADH2 + dioxygen→a 4,5-dichloro-1H-pyrrole-2-carbonyl-[PltL prolyl-carrier protein] + FAD + 2 H2O (EC 1.14.19.56)
No genes
a 4,5-dichloro-1H-pyrrole-2-carbonyl-[PltL prolyl-carrier protein] + 3 malonyl-CoA + NADPH + 4 H+→a 7-(4,5-dichloro-1H-pyrrol-2-yl)-3-hydroxy-5,7-dioxoheptanoyl-[PltL prolyl-carrier protein] + 3 CO2 + 3 coenzyme A + NADP+
No genes
a 7-(4,5-dichloro-1H-pyrrol-2-yl)-3-hydroxy-5,7-dioxoheptanoyl-[PltL prolyl-carrier protein]→pyoluteorin + a holo-[PltL prolyl-carrier protein] + H2O
No genes

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information