MetaCyc Pathway: procollagen hydroxylation and glycosylation in Cupriavidus basilensis FW507-4G11

Add experiment(s):


Procollagen-lysine 5-dioxygenase:
a [procollagen]-L-lysine + 2-oxoglutarate + dioxygen→a [procollagen]-(5R)-5-hydroxy-L-lysine + CO2 + succinate (EC 1.14.11.4)
No genes
Procollagen-proline 3-dioxygenase:
a [procollagen]-L-proline + 2-oxoglutarate + dioxygen→a [procollagen]-trans-3-hydroxy-L-proline + CO2 + succinate (EC 1.14.11.7)
No genes
Procollagen-proline dioxygenase:
a [procollagen]-L-proline + 2-oxoglutarate + dioxygen→a [procollagen] trans 4-hyroxy-L-proline + CO2 + succinate (EC 1.14.11.2)
RR42_RS17915
Procollagen galactosyltransferase:
a [procollagen]-(5R)-5-hydroxy-L-lysine + UDP-α-D-galactose→a [procollagen]-(5R)-5-O-(β-D-galactosyloxy)-L-lysine + H+ + UDP (EC 2.4.1.50)
No genes
Procollagen glucosyltransferase:
a [procollagen]-(5R)-5-O-(β-D-galactosyloxy)-L-lysine + UDP-α-D-glucose→a [procollagen]-(5R)-5-O-[α-D-glucosyl-(1→2)-β-D-galactosyl]-5-hydroxy-L-lysine + H+ + UDP (EC 2.4.1.66)
No genes
Protein-glucosylgalactosylhydroxylysine glucosidase:
a [procollagen]-(5R)-5-O-[α-D-glucosyl-(1→2)-β-D-galactosyl]-5-hydroxy-L-lysine + H2O→a [procollagen]-(5R)-5-O-(β-D-galactosyloxy)-L-lysine + D-glucopyranose (EC 3.2.1.107)
No genes

Links:

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information