MetaCyc Pathway: globo-series glycosphingolipids biosynthesis in Cupriavidus basilensis FW507-4G11

Add experiment(s):


Ceramide glucosyltransferase:
an N-acylsphingosine + UDP-α-D-glucose→a β-D-glucosyl-N-acylsphingosine + H+ + UDP (EC 2.4.1.80)
RR42_RS35290
a β-D-glucosyl-N-acylsphingosine + UDP-α-D-galactose→a lactosylceramide + H+ + UDP (EC 2.4.1.274)
No genes
Lactosylceramide 4-alpha-galactosyltransferase:
a lactosylceramide + UDP-α-D-galactose→a globotriosylceramide + H+ + UDP (EC 2.4.1.228)
No genes
Globotriaosylceramide 3-beta-N-acetylgalactosaminyltransferase:
a globotriosylceramide + UDP-N-acetyl-α-D-galactosamine→a globotetraosylceramide + H+ + UDP (EC 2.4.1.79)
No genes
Globoside alpha-N-acetylgalactosaminyltransferase:
a globotetraosylceramide + UDP-N-acetyl-α-D-galactosamine→Forssman globoside + H+ + UDP (EC 2.4.1.88)
No genes
a globotetraosylceramide + UDP-α-D-galactose→SSEA-3 + H+ + UDP
No genes
SSEA-3 + CMP-N-acetyl-β-neuraminate→SSEA-4 + CMP + H+ (EC 2.4.3.4)
No genes
SSEA-3 + GDP-β-L-fucose→globo H + GDP + H+
No genes

Links:

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information