MetaCyc Pathway: superpathway of glycosphingolipids biosynthesis in Cupriavidus basilensis FW507-4G11

Add experiment(s):


Ceramide glucosyltransferase:
an N-acylsphingosine + UDP-α-D-glucose→a β-D-glucosyl-N-acylsphingosine + H+ + UDP (EC 2.4.1.80)
RR42_RS35290
a β-D-glucosyl-N-acylsphingosine + UDP-α-D-galactose→a lactosylceramide + H+ + UDP (EC 2.4.1.274)
No genes
Lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase:
a lactosylceramide + UDP-N-acetyl-α-D-glucosamine→a lactotriaosylceramide + H+ + UDP (EC 2.4.1.206)
No genes
Lactosylceramide 4-alpha-galactosyltransferase:
a lactosylceramide + UDP-α-D-galactose→a globotriosylceramide + H+ + UDP (EC 2.4.1.228)
No genes
a lactosylceramide + CMP-N-acetyl-β-neuraminate→an N-acetyl-α-neuraminyl-(2→6)-β-galactosyl-(1→4)-β-D-glucosyl-(1↔1)-ceramide + CMP + H+ (EC 2.4.3.1)
No genes
a lactosylceramide + CMP-N-acetyl-β-neuraminate→a ganglioside GM3 + CMP + H+ (EC 2.4.3.9)
No genes
N-acetylgalactosaminyltransferase:
a lactosylceramide + UDP-N-acetyl-α-D-galactosamine→a ganglioside GA2 + H+ + UDP (EC 2.4.1.92)
No genes
Globotriaosylceramide 3-beta-N-acetylgalactosaminyltransferase:
a globotriosylceramide + UDP-N-acetyl-α-D-galactosamine→a globotetraosylceramide + H+ + UDP (EC 2.4.1.79)
No genes
Glucosaminylgalactosylglucosylceramide beta-galactosyltransferase:
a lactotriaosylceramide + UDP-α-D-galactose→a lactotetraosylceramide + H+ + UDP (EC 2.4.1.86)
No genes
N-acetylgalactosaminyltransferase:
a ganglioside GM3 + UDP-N-acetyl-α-D-galactosamine→a ganglioside GM2 + H+ + UDP (EC 2.4.1.92)
No genes
a lactotriaosylceramide + UDP-α-D-galactose→a neolactotetraosylceramide + H+ + UDP (EC 2.4.1.275)
No genes
Ganglioside galactosyltransferase:
a ganglioside GA2 + UDP-α-D-galactose→a ganglioside GA1 + H+ + UDP (EC 2.4.1.62)
No genes
a ganglioside GM3 + CMP-N-acetyl-β-neuraminate→a ganglioside GD3 + CMP + H+ (EC 2.4.3.8)
No genes
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase:
a neolactotetraosylceramide + UDP-N-acetyl-α-D-glucosamine→a neolactopentaosylceramide + H+ + UDP (EC 2.4.1.149)
No genes
Globoside alpha-N-acetylgalactosaminyltransferase:
a globotetraosylceramide + UDP-N-acetyl-α-D-galactosamine→Forssman globoside + H+ + UDP (EC 2.4.1.88)
No genes
a neolactotetraosylceramide + CMP-N-acetyl-β-neuraminate→a ganglioside LM1 + CMP + H+ (EC 2.4.3.6)
No genes
Galactoside 2-alpha-L-fucosyltransferase:
a lactotetraosylceramide + GDP-β-L-fucose→a III2-α-fucosyllactotetraosylceramide + GDP + H+ (EC 2.4.1.69)
No genes
Ganglioside galactosyltransferase:
a ganglioside GM2 + UDP-α-D-galactose→a ganglioside GM1a + H+ + UDP (EC 2.4.1.62)
No genes
N-acetylgalactosaminyltransferase:
a ganglioside GD3 + UDP-N-acetyl-α-D-galactosamine→a ganglioside GD2 + H+ + UDP (EC 2.4.1.92)
No genes
a ganglioside GD3 + CMP-N-acetyl-β-neuraminate→a ganglioside GT3 + CMP + H+ (EC 2.4.3.8)
No genes
a ganglioside GA1 + CMP-N-acetyl-β-neuraminate→a ganglioside GM1b + CMP + H+ (EC 2.4.3.4)
No genes
a globotetraosylceramide + UDP-α-D-galactose→SSEA-3 + H+ + UDP
No genes
a lactotetraosylceramide + CMP-N-acetyl-β-neuraminate→a ganglioside 3'-isoLM1 + CMP + H+ (EC 2.4.3.9)
No genes
a neolactotetraosylceramide + CMP-N-acetyl-β-neuraminate→a ganglioside 6'-LM1 + CMP + H+ (EC 2.4.3.1)
No genes
a ganglioside GM1a + CMP-N-acetyl-β-neuraminate→a ganglioside GD1a + CMP + H+ (EC 2.4.3.2)
No genes
Ganglioside galactosyltransferase:
a ganglioside GD2 + UDP-α-D-galactose→a ganglioside GD1b + H+ + UDP (EC 2.4.1.62)
No genes
a ganglioside GM1b + CMP-N-acetyl-β-neuraminate→a ganglioside GD1c + CMP + H+ (EC 2.4.3.8)
No genes
N-acetylgalactosaminyltransferase:
a ganglioside GT3 + UDP-N-acetyl-α-D-galactosamine→a ganglioside GT2 + H+ + UDP (EC 2.4.1.92)
No genes
SSEA-3 + CMP-N-acetyl-β-neuraminate→SSEA-4 + CMP + H+ (EC 2.4.3.4)
No genes
SSEA-3 + GDP-β-L-fucose→globo H + GDP + H+
No genes
a neolactopentaosylceramide + UDP-α-D-galactose→a neolactohexaosylceramide + H+ + UDP (EC 2.4.1.275)
No genes
a ganglioside 3'-isoLM1 + CMP-N-acetyl-β-neuraminate→a ganglioside 3',6'-isoLD1 + CMP + H+ (EC 2.4.3.1)
No genes
a ganglioside GD1b + CMP-N-acetyl-β-neuraminate→a ganglioside GT1b + CMP + H+ (EC 2.4.3.2)
No genes
a ganglioside GD1a + CMP-N-acetyl-β-neuraminate→a ganglioside GT1a + CMP + H+ (EC 2.4.3.8)
No genes
Ganglioside galactosyltransferase:
a ganglioside GT2 + UDP-α-D-galactose→a ganglioside GT1c + H+ + UDP (EC 2.4.1.62)
No genes
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase:
a neolactohexaosylceramide + UDP-N-acetyl-α-D-glucosamine→a neolactoheptaosylceramide + H+ + UDP (EC 2.4.1.149)
No genes
a neolactohexaosylceramide + CMP-N-acetyl-β-neuraminate→a sialyl-(2,3)-neolactohexaosylceramide + CMP + H+ (EC 2.4.3.6)
No genes
a ganglioside GT1b + CMP-N-acetyl-β-neuraminate→a ganglioside GQ1b + CMP + H+ (EC 2.4.3.8)
No genes
a ganglioside GT1c + CMP-N-acetyl-β-neuraminate→a ganglioside GQ1c + CMP + H+ (EC 2.4.3.2)
No genes
a neolactoheptaosylceramide + UDP-α-D-galactose→a neolactooctaosylceramide + H+ + UDP (EC 2.4.1.275)
No genes
a ganglioside GQ1c + CMP-N-acetyl-β-neuraminate→a ganglioside GP1c + CMP + H+ (EC 2.4.3.8)
No genes
a neolactooctaosylceramide + CMP-N-acetyl-β-neuraminate→a sialyl-(2,3)-neolactoheptaosylceramide + CMP + H+ (EC 2.4.3.6)
No genes

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information