| 4-coumarate + dioxygen + a reduced [NADPH-hemoprotein reductase]→trans-caffeate + an oxidized [NADPH-hemoprotein reductase] + H2O (EC 1.14.14.96) |
| No genes |
Tyrosine decarboxylase:
L-tyrosine + H+→tyramine + CO2 (EC 4.1.1.25; 4.1.1.28) |
| RR42_RS26695 |
4-coumarate--CoA ligase:
trans-caffeate + ATP + coenzyme A→(E)-caffeoyl-CoA + AMP + diphosphate (EC 6.2.1.12) |
| RR42_RS36410 |
| (E)-caffeoyl-CoA + H2O→3,4-dihydroxybenzaldehyde + acetyl-CoA (EC 4.1.2.61) |
| No genes |
| 3,4-dihydroxybenzaldehyde + tyramine→norcraugsodine + H+ + H2O |
| No genes |
| norcraugsodine + a reduced two electron carrier→norbelladine + an oxidized electron carrier |
| No genes |
| norbelladine + S-adenosyl-L-methionine→4'-O-methylnorbelladine + S-adenosyl-L-homocysteine + H+ (EC 2.1.1.336) |
| No genes |
| 4'-O-methylnorbelladine + dioxygen + a reduced [NADPH-hemoprotein reductase]→N-demethylnarwedine + an oxidized [NADPH-hemoprotein reductase] + 2 H2O |
| No genes |
| 4'-O-methylnorbelladine + dioxygen + a reduced [NADPH-hemoprotein reductase]→(4aR,10bS)-noroxomaritidine + an oxidized [NADPH-hemoprotein reductase] + 2 H2O (EC 1.14.19.50) |
| No genes |
| 4'-O-methylnorbelladine + dioxygen + a reduced [NADPH-hemoprotein reductase]→noroxopluviine + an oxidized [NADPH-hemoprotein reductase] + 2 H2O |
| No genes |
| 4'-O-methylnorbelladine + dioxygen + a reduced [NADPH-hemoprotein reductase]→(4aS,10bR)-noroxomaritidine + an oxidized [NADPH-hemoprotein reductase] + 2 H2O (EC 1.14.19.50) |
| No genes |
| N-demethylnarwedine + a reduced two electron carrier→N-demethylgalanthamine + an oxidized electron carrier |
| No genes |
| (4aR,10bS)-noroxomaritidine + NADPH + H+→(10bS,4aR)-oxomaritinamine + NADP+ |
| No genes |
| (4aS,10bR)-noroxomaritidine + a reduced two electron carrier→(-)-8-demethylmaritidine + an oxidized electron carrier |
| No genes |
| noroxopluviine + a reduced two electron carrier→(1S,15R,16S)-4-methoxy-9-azatetracyclo[7.6.1.02,7.012,16]hexadeca-2,4,6,12-tetraene-5,15-diol + an oxidized electron carrier |
| No genes |
| (4aR,10bS)-noroxomaritidine + a reduced two electron carrier→(10bS, 4aR)-normaritidine + an oxidized electron carrier |
| No genes |
| (4aS,10bR)-noroxomaritidine + NADPH + H+→(10bR,4aS)-oxomaritinamine + NADP+ |
| No genes |
| N-demethylgalanthamine + S-adenosyl-L-methionine→galanthamine + S-adenosyl-L-homocysteine + H+ |
| No genes |
| (10bR,4aS)-oxomaritinamine + a reduced two electron carrier→maritinamine + an oxidized electron carrier |
| No genes |
| (10bS,4aR)-oxomaritinamine + a reduced two electron carrier→elwesine + an oxidized electron carrier |
| No genes |
| (10bS, 4aR)-normaritidine + dioxygen + a reduced [NADPH-hemoprotein reductase]→crinine + an oxidized [NADPH-hemoprotein reductase] + 2 H2O |
| No genes |
| (-)-8-demethylmaritidine + dioxygen + a reduced [NADPH-hemoprotein reductase]→vittatine + an oxidized [NADPH-hemoprotein reductase] + 2 H2O |
| No genes |
| (1S,15R,16S)-4-methoxy-9-azatetracyclo[7.6.1.02,7.012,16]hexadeca-2,4,6,12-tetraene-5,15-diol + dioxygen + a reduced [NADPH-hemoprotein reductase]→caranine + an oxidized [NADPH-hemoprotein reductase] + 2 H2O |
| No genes |
| vittatine + dioxygen + a reduced [NADPH-hemoprotein reductase]→11-hydroxyvittatine + an oxidized [NADPH-hemoprotein reductase] + H2O |
| No genes |
| caranine + NADPH + dioxygen + H+→lycorine + NADP+ + H2O |
| No genes |
| 11-hydroxyvittatine + S-adenosyl-L-methionine→hemanthamine + S-adenosyl-L-homocysteine + H+ |
| No genes |
Links:
Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information