MetaCyc Pathway: poly(ribitol phosphate) wall teichoic acid biosynthesis II (S. aureus) in Cupriavidus basilensis FW507-4G11

Add experiment(s):


Glycerol-3-phosphate cytidylyltransferase:
sn-glycerol 3-phosphate + CTP + H+→(2R)-CDP-glycerol + diphosphate (EC 2.7.7.39)
RR42_RS00710
di-trans,octa-cis-undecaprenyl phosphate + UDP-N-acetyl-α-D-glucosamine→α-D-GlcNAc-PP-Und + UMP (EC 2.7.8.33)
No genes
D-alanine + ATP + a holo [D-alanyl carrier protein]→a D-alanyl-[D-alanyl carrier protein] + AMP + diphosphate (EC 6.2.1.54)
No genes
a D-alanyl-[D-alanyl carrier protein] + a phosphatidylglycerol[membrane]→2-O-D-alanyl-1-O-phosphatidylglycerol[out] + a holo [D-alanyl carrier protein][in] (EC 2.3.2.M5)
No genes
mannosaminyltransferase:
α-D-GlcNAc-PP-Und + UDP-N-acetyl-α-D-mannosamine→β-D-ManNAc-(1→4)-α-D-GlcNAc-PP-Und + H+ + UDP (EC 2.4.1.187)
RR42_RS33210
β-D-ManNAc-(1→4)-α-D-GlcNAc-PP-Und + (2R)-CDP-glycerol→Gro-P-β-D-ManNAc-(1→4)-α-D-GlcNAc-PP-Und + CMP + H+ (EC 2.7.8.44)
No genes
Gro-P-β-D-ManNAc-(1→4)-α-D-GlcNAc-PP-Und + (2R)-CDP-glycerol→Gro-P-Gro-P-ManNAc-GlcNAc-PP-undecaprenol + CMP + H+ (EC 2.7.8.45)
No genes
CDP-ribitol ribitolphosphotransferase:
Gro-P-Gro-P-ManNAc-GlcNAc-PP-undecaprenol + CDP-ribitol→Rib-ol-P-Gro-P-Gro-P-ManNAc-GlcNAc-PP-undecaprenol + CMP + H+ (EC 2.7.8.14)
No genes
CDP-ribitol ribitolphosphotransferase:
n-1 CDP-ribitol + Rib-ol-P-Gro-P-Gro-P-ManNAc-GlcNAc-PP-undecaprenol→(Rib-ol-P)n-(Rib-ol)-P-Gro-P-Gro-P-ManNAc-GlcNAc-PP-undecaprenol + n-1 CMP + n-1 H+ (EC 2.7.8.14)
No genes
Poly(ribitol-phosphate) N-acetylglucosaminyltransferase:
(Rib-ol-P)n-(Rib-ol)-P-Gro-P-Gro-P-ManNAc-GlcNAc-PP-undecaprenol + n UDP-N-acetyl-α-D-glucosamine→(Rib-ol-P)n-[2-(αGlcNac)-Rib-ol-P]-Gro-P-Gro-P-ManNAc-GlcNAc-PP-undecaprenol + H+ + UDP (EC 2.4.1.70)
No genes
(Rib-ol-P)n-[2-(αGlcNac)-Rib-ol-P]-Gro-P-Gro-P-ManNAc-GlcNAc-PP-undecaprenol + n UDP-N-acetyl-α-D-glucosamine→[2-(βGlcNac)-Rib-ol-P]n-[2-(αGlcNac)-Rib-ol-P]-Gro-P-Gro-P-ManNAc-GlcNAc-PP-undecaprenol + n H+ + n UDP (EC 2.4.1.355)
No genes
[2-(βGlcNac)-Rib-ol-P]n-[2-(αGlcNac)-Rib-ol-P]-Gro-P-Gro-P-ManNAc-GlcNAc-PP-undecaprenol[in] + ATP[in] + H2O[in]→[2-(βGlcNac)-Rib-ol-P]n-[2-(αGlcNac)-Rib-ol-P]-Gro-P-Gro-P-ManNAc-GlcNAc-PP-undecaprenol[out] + ADP[in] + H+[in] + phosphate[in] (EC 7.5.2.4)
No genes
2-O-D-alanyl-1-O-phosphatidylglycerol + [2-(βGlcNac)-Rib-ol-P]n-[2-(αGlcNac)-Rib-ol-P]-Gro-P-Gro-P-ManNAc-GlcNAc-PP-undecaprenol→polyisoprenyl-poly(ribitol phosphate) teichoic acid (S. aureus) + a phosphatidylglycerol (EC 2.3.1.M32)
No genes
polyisoprenyl-poly(ribitol phosphate) teichoic acid (S. aureus) + Und-PP-[β-D-GlcNAc-(1→4)]-MurNAc-L-Ala-γ-D-iGln-(6-N-Gly5)-L-Lys-D-Ala-D-Ala + H2O→di-trans,octa-cis-undecaprenyl phosphate + [(4-D-Ala)-(2-GlcNAc)-Rib-ol-P]n-Gro-P-Gro-P-β-D-ManNAc-(1→4)-α-D-GlcNAc-P-peptidoglycan + 2 H+ + di-trans,octa-cis-undecaprenyl diphosphate (EC 2.7.8.M1)
No genes

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information