MetaCyc Pathway: phenolphthiocerol biosynthesis in Cupriavidus basilensis FW507-4G11

Add experiment(s):


Chorismate lyase:
chorismate→4-hydroxybenzoate + pyruvate (EC 4.1.3.40)
RR42_RS17665
4-hydroxybenzoate + ATP + H+→4-hydroxybenzoyl-adenylate + diphosphate (EC 6.2.1.50)
No genes
4-hydroxybenzoyl-adenylate + a holo-[4-hydroxyphenylalkanoate synthase]→4-hydroxybenzoyl-[4-hydroxyphenylalkanoate synthase] + AMP + H+ (EC 6.2.1.50)
No genes
4-hydroxybenzoyl-[4-hydroxyphenylalkanoate synthase] + 8 malonyl-CoA + 16 NADPH + 24 H+→17-(4-hydroxyphenyl)heptadecanoyl-[4-hydroxyphenylalkanoate synthase] + 8 CO2 + 8 coenzyme A + 16 NADP+ + 8 H2O (EC 2.3.1.261)
No genes
4-hydroxybenzoyl-[4-hydroxyphenylalkanoate synthase] + 9 malonyl-CoA + 18 NADPH + 27 H+→19-(4-hydroxyphenyl)nonadecanoyl-[4-hydroxyphenylalkanoate synthase] + 9 CO2 + 9 coenzyme A + 18 NADP+ + 9 H2O (EC 2.3.1.261)
No genes
17-(4-hydroxyphenyl)heptadecanoyl-[4-hydroxyphenylalkanoate synthase] + H2O→17-(4-hydroxyphenyl)heptadecanoate + a holo-[4-hydroxyphenylalkanoate synthase] + H+ (EC 3.1.2.M1)
No genes
19-(4-hydroxyphenyl)nonadecanoyl-[4-hydroxyphenylalkanoate synthase] + H2O→19-(4-hydroxyphenyl)nonadecanoate + a holo-[4-hydroxyphenylalkanoate synthase] + H+ (EC 3.1.2.M1)
No genes
17-(4-hydroxyphenyl)heptadecanoate + ATP + H+→17-(4-hydroxyphenyl)heptadecanoyl adenylate + diphosphate (EC 6.2.1.51)
No genes
19-(4-hydroxyphenyl)nonadecanoate + ATP + H+→19-(4-hydroxyphenyl)nonadecanoyl adenylate + diphosphate (EC 6.2.1.51)
No genes
19-(4-hydroxyphenyl)nonadecanoyl adenylate + a holo-[(phenol)carboxyphthiodiolenone synthase]→a 19-(4-hydroxyphenyl)-nonadecanoyl-[(phenol)carboxyphthiodiolenone synthase] + AMP + H+ (EC 6.2.1.51)
No genes
17-(4-hydroxyphenyl)heptadecanoyl adenylate + a holo-[(phenol)carboxyphthiodiolenone synthase]→a 17-(4-hydroxyphenyl)heptadecanoyl-[(phenol)carboxyphthiodiolenone synthase] + AMP + H+ (EC 6.2.1.51)
No genes
a 17-(4-hydroxyphenyl)heptadecanoyl-[(phenol)carboxyphthiodiolenone synthase] + 2 (S)-methylmalonyl-CoA + 3 malonyl-CoA + 5 NADPH + 10 H+→a C35-phenolcarboxyphthiodiolenone-[(phenol)carboxyphthiodiolenone synthase] + 5 CO2 + 5 coenzyme A + 5 NADP+ + 2 H2O (EC 2.3.1.292)
No genes
a 19-(4-hydroxyphenyl)-nonadecanoyl-[(phenol)carboxyphthiodiolenone synthase] + 2 (S)-methylmalonyl-CoA + 3 malonyl-CoA + 5 NADPH + 10 H+→a C37-phenolcarboxyphthiodiolenone-[(phenol)carboxyphthiodiolenone synthase] + 5 CO2 + 5 coenzyme A + 5 NADP+ + 2 H2O (EC 2.3.1.292)
No genes
a C35-phenolcarboxyphthiodiolenone-[(phenol)carboxyphthiodiolenone synthase] + H2O→C35-phenolcarboxyphthiodiolenone + H+ + a holo-[(phenol)carboxyphthiodiolenone synthase] (EC 3.1.2.M1)
No genes
a C37-phenolcarboxyphthiodiolenone-[(phenol)carboxyphthiodiolenone synthase] + H2O→C37-phenolcarboxyphthiodiolenone + H+ + a holo-[(phenol)carboxyphthiodiolenone synthase] (EC 3.1.2.M1)
No genes
C35-phenolcarboxyphthiodiolenone + H+→C34-phenolphthiodiolenone A + CO2 (EC 4.1.1.M4)
No genes
C37-phenolcarboxyphthiodiolenone + H+→C36-phenolphthiodiolenone A + CO2 (EC 4.1.1.M4)
No genes
C34-phenolphthiodiolenone A + NADPH + H+→C34-phenolphthiodiolone A + NADP+ (EC 1.1.1.M10)
No genes
C36-phenolphthiodiolenone A + NADPH + H+→C36-phenolphthiodiolone A + NADP+ (EC 1.1.1.M10)
No genes
C34-phenolphthiodiolone A + NADPH + H+→C34-phenolphthiotriol A + NADP+ (EC 1.1.1.M11)
No genes
C36-phenolphthiodiolone A + NADPH + H+→C36-phenolphthiotriol A + NADP+ (EC 1.1.1.M11)
No genes
C34-phenolphthiotriol A + S-adenosyl-L-methionine→C35-phenolphthiocerol A + S-adenosyl-L-homocysteine + H+ (EC 2.1.1.M12)
No genes
C36-phenolphthiotriol A + S-adenosyl-L-methionine→C37-phenolphthiocerol A + S-adenosyl-L-homocysteine + H+ (EC 2.1.1.M12)
No genes

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information