MetaCyc Pathway: thiocoraline biosynthesis in Cupriavidus basilensis FW507-4G11

Add experiment(s):


Cysteine--tRNA ligase:
L-cysteine + ATP + H+→(L-cysteinyl)adenylate + diphosphate (EC 6.1.1.16; 6.2.1.69)
RR42_RS06350
3-hydroxyquinaldate + ATP + H+→3-hydroxyquinaldate adenylate + diphosphate
No genes
3-hydroxyquinaldate adenylate + an aryl-carrier protein→a 3-hydroxyquinaldyl-[aryl-carrier protein] + AMP + H+
No genes
(L-cysteinyl)adenylate + S-adenosyl-L-methionine→(S-methyl-L-cysteinyl)adenylate + S-adenosyl-L-homocysteine + H+
No genes
a 3-hydroxyquinaldyl-[aryl-carrier protein] + L-cysteine + glycine + 2 ATP + a non-ribosomal peptide synthase→a 3-hydroxyquinaldyl-D-cysteinyl-glycyl-[non-ribosomal peptide synthase] + 2 AMP + an aryl-carrier protein + 2 diphosphate + 2 H+
No genes
2 (S-methyl-L-cysteinyl)adenylate + 2 L-cysteine + 2 a 3-hydroxyquinaldyl-D-cysteinyl-glycyl-[non-ribosomal peptide synthase] + 2 ATP + 4 S-adenosyl-L-methionine→thiocoraline dithiol + 4 S-adenosyl-L-homocysteine + 4 AMP + 2 a non-ribosomal peptide synthase + 2 diphosphate + 10 H+
No genes
thiocoraline dithiol + dioxygen→thiocoraline + hydrogen peroxide
No genes

Links:

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information