MetaCyc Pathway: quinoxaline-2-carboxylate biosynthesis in Cupriavidus basilensis FW507-4G11

Add experiment(s):


L-tryptophan + ATP + a holo-[L-tryptophyl-carrier protein]→an L-tryptophyl-[L-tryptophyl-carrier protein] + AMP + diphosphate (EC 6.2.1.73)
No genes
an L-tryptophyl-[L-tryptophyl-carrier protein] + NADPH + dioxygen + H+→an (S)-β-hydroxy-L-tryptophyl-[L-tryptophyl-carrier protein] + NADP+ + H2O
No genes
an (S)-β-hydroxy-L-tryptophyl-[L-tryptophyl-carrier protein] + H2O→(S)-β-hydroxy-L-tryptophan + a holo-[L-tryptophyl-carrier protein] + H+
No genes
(S)-β-hydroxy-L-tryptophan + dioxygen→(R)-N-formyl-β-hydroxy-L-kynurenine
No genes
Arylformamidase:
(R)-N-formyl-β-hydroxy-L-kynurenine + H2O→(R)-β-hydroxy-L-kynurenine + formate + H+ (EC 3.5.1.9)
RR42_RS15380
RR42_RS33590
(R)-β-hydroxy-L-kynurenine + FAD + H2O→(2S,3R)-2-[(2-aminophenyl)amino]-3-carboxy-3-hydroxypropanoate + FADH2 + H+
No genes
(2S,3R)-2-[(2-aminophenyl)amino]-3-carboxy-3-hydroxypropanoate + NAD+→(2S,3R)-2-[(2-aminophenyl)amino]-3-carboxy-3-oxopropanoate + NADH + H+
No genes
(2S,3R)-2-[(2-aminophenyl)amino]-3-carboxy-3-oxopropanoate + H+→3-[(2-aminophenyl)amino]-2-oxopropanoate + CO2 (spontaneous)
No genes
3-[(2-aminophenyl)amino]-2-oxopropanoate→3,4-dihydroquinoxaline-2-carboxylate + H2O (spontaneous)
No genes
3,4-dihydroquinoxaline-2-carboxylate + an oxidized electron carrier→quinoxaline-2-carboxylate + a reduced two electron carrier (spontaneous)
No genes

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information