MetaCyc Pathway: 3-hydroxyquinaldate biosynthesis in Cupriavidus basilensis FW507-4G11

Add experiment(s):


L-tryptophan + ATP + a holo-[L-tryptophyl-carrier protein]→an L-tryptophyl-[L-tryptophyl-carrier protein] + AMP + diphosphate (EC 6.2.1.73)
No genes
an L-tryptophyl-[L-tryptophyl-carrier protein] + NADPH + dioxygen + H+→an (S)-β-hydroxy-L-tryptophyl-[L-tryptophyl-carrier protein] + NADP+ + H2O
No genes
an (S)-β-hydroxy-L-tryptophyl-[L-tryptophyl-carrier protein] + H2O→(S)-β-hydroxy-L-tryptophan + a holo-[L-tryptophyl-carrier protein] + H+
No genes
(S)-β-hydroxy-L-tryptophan + dioxygen→(R)-N-formyl-β-hydroxy-L-kynurenine
No genes
Arylformamidase:
(R)-N-formyl-β-hydroxy-L-kynurenine + H2O→(R)-β-hydroxy-L-kynurenine + formate + H+
(EC 3.5.1.9)
RR42_RS15380
RR42_RS33590
(R)-β-hydroxy-L-kynurenine + 2-oxoglutarate→(3R)-4-(2-aminophenyl)-3-hydroxy-2,4-dioxobutanoate + L-glutamate
No genes
(3R)-4-(2-aminophenyl)-3-hydroxy-2,4-dioxobutanoate→3-hydroxykynurenate + H2O (spontaneous)
No genes
3-hydroxykynurenate + NADPH + H+→3-hydroxyquinaldate + NADP+ + H2O
No genes

Links:

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information