MetaCyc Pathway: 3-hydroxy-4-methyl-anthranilate biosynthesis I in Cupriavidus basilensis FW507-4G11

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Tryptophan 2,3-dioxygenase:
L-tryptophan + dioxygen→N-formyl-L-kynurenine (EC 1.13.11.11; 1.13.11.52)
RR42_RS15390
Arylformamidase:
N-formyl-L-kynurenine + H2O→L-kynurenine + formate + H+ (EC 3.5.1.9)
RR42_RS15380
RR42_RS33590
Kynurenine 3-monooxygenase:
L-kynurenine + NADPH + dioxygen + H+→3-hydroxy-L-kynurenine + NADP+ + H2O (EC 1.14.13.9)
No genes
3-hydroxy-L-kynurenine→3-hydroxy-D-kynurenine
No genes
3-hydroxy-D-kynurenine + S-adenosyl-L-methionine→3-hydroxy-4-methyl-D-kynurenine + S-adenosyl-L-homocysteine + H+ (EC 2.1.1.M8)
No genes
3-hydroxy-4-methyl-D-kynurenine + H2O→3-hydroxy-4-methylanthranilate + L-alanine + H+
No genes

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information