MetaCyc Pathway: arachidonate biosynthesis III (6-desaturase, mammals) in Cupriavidus basilensis FW507-4G11

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Long-chain-fatty-acid--CoA ligase:
linoleate + ATP + coenzyme A→linoleoyl-CoA + AMP + diphosphate (EC 6.2.1.3)
RR42_RS01625
RR42_RS18150
RR42_RS18540
RR42_RS25195
RR42_RS26915
RR42_RS28980
RR42_RS29035
RR42_RS29460
RR42_RS29475
RR42_RS36095
RR42_RS36385
RR42_RS36505
Linoleoyl-CoA desaturase:
linoleoyl-CoA + 2 a ferrocytochrome b5 + dioxygen + 2 H+→γ-linolenoyl-CoA + 2 a ferricytochrome b5 + 2 H2O (EC 1.14.19.3)
No genes
γ-linolenoyl-CoA + malonyl-CoA + H+→3-oxodihomo γ-linolenoyl-CoA + CO2 + coenzyme A
No genes
3-oxodihomo γ-linolenoyl-CoA + NAD(P)H + H+→(3R)-hydroxydihomo γ-linolenoyl-CoA + NAD(P)+ (EC 1.1.1.330)
No genes
(3R)-hydroxydihomo γ-linolenoyl-CoA→(2E,8Z,11Z,14Z)-icosatetraenoyl-CoA + H2O (EC 4.2.1.134)
No genes
(2E,8Z,11Z,14Z)-icosatetraenoyl-CoA + NADH + H+→dihomo γ-linolenoyl-CoA + NAD+ (EC 1.3.1.93)
No genes
dihomo γ-linolenoyl-CoA + 2 a ferrocytochrome b5 + dioxygen + 2 H+→arachidonoyl-CoA + 2 a ferricytochrome b5 + 2 H2O (EC 1.14.19.44)
No genes

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information