MetaCyc Pathway: ergothioneine biosynthesis II (fungi) in Cupriavidus basilensis FW507-4G11

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Dimethylhistidine N-methyltransferase:
L-histidine + 3 S-adenosyl-L-methionine→hercynine + 3 S-adenosyl-L-homocysteine + 3 H+ (EC 2.1.1.44)
RR42_RS14730
hercynine + L-cysteine + dioxygen→S-(hercyn-2-yl)-L-cysteine S-oxide + H2O (EC 1.21.3.10)
No genes
S-(hercyn-2-yl)-L-cysteine S-oxide + H2O→2-(hydroxysulfanyl)hercynine + ammonium + pyruvate (EC 4.4.1.36)
No genes
2-(hydroxysulfanyl)hercynine + a reduced two electron carrier→ergothioneine + an oxidized electron carrier + H2O (spontaneous) (EC 4.4.1.36)
No genes
ergothioneine→ergothioneine (thione form) (spontaneous)
No genes

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information