MetaCyc Pathway: 1,2-propanediol biosynthesis from lactate (engineered) in Cupriavidus basilensis FW507-4G11

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Propionate CoA-transferase:
(R)-lactate + acetyl-CoA→(R)-lactoyl-CoA + acetate (EC 2.8.3.1)
RR42_RS10720
RR42_RS14835
Propionate CoA-transferase:
(S)-lactate + acetyl-CoA→(S)-lactoyl-CoA + acetate (EC 2.8.3.1)
RR42_RS10720
RR42_RS14835
(R)-lactoyl-CoA + NADH + H+→(R)-lactaldehyde + coenzyme A + NAD+ (EC 1.2.1.87)
No genes
(S)-lactoyl-CoA + NADH + H+→(S)-lactaldehyde + coenzyme A + NAD+ (EC 1.2.1.87)
No genes
(R)-lactaldehyde + NADPH + H+→(R)-propane-1,2-diol + NADP+
No genes
Lactaldehyde reductase (NADPH) (in reverse):
(S)-lactaldehyde + NADPH + H+→(S)-propane-1,2-diol + NADP+ (EC 1.1.1.55)
No genes

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information