MetaCyc Pathway: 6-hydroxymethyl-dihydropterin diphosphate biosynthesis III (Chlamydia) in Cupriavidus basilensis FW507-4G11

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GTP cyclohydrolase II:
GTP + 4 H2O→2,5-diamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one + formate + 3 H+ + 2 phosphate (EC 3.5.4.25)
RR42_RS03685
RR42_RS15565
RR42_RS29255
RR42_RS32045
RR42_RS33350
2,5-diamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one→7,8-dihydroneopterin 3'-phosphate + H2O (EC 4.2.1.160)
No genes
7,8-dihydroneopterin 3'-phosphate + H2O→D-erythro-7,8-dihydroneopterin + phosphate
No genes
Dihydroneopterin aldolase:
D-erythro-7,8-dihydroneopterin→6-(hydroxymethyl)-7,8-dihydropterin + glycolaldehyde (EC 4.1.2.25)
RR42_RS01440
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase:
6-(hydroxymethyl)-7,8-dihydropterin + ATP→(7,8-dihydropterin-6-yl)methyl diphosphate + AMP + H+ (EC 2.7.6.3)
RR42_RS17240

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information