| malonyl-CoA + H+→acetyl-CoA + CO2 (EC 2.3.1.235; 4.1.1.9) |
| RR42_RS16185 |
| acetyl-CoA + 9 malonyl-CoA + 8 H+ + H2O→3,5,7,9,11,13,15,17,19-nonaoxoicosanoate + 9 CO2 + 10 coenzyme A (EC 2.3.1.235) |
| No genes |
| 3,5,7,9,11,13,15,17,19-nonaoxoicosanoate→3,5-dioxo-6-[4,5,7-trihydroxy-3-(3-oxobutanoyl)naphthalen-2-yl]hexanoate + 2 H2O (EC 2.3.1.235) |
| No genes |
| 3,5-dioxo-6-[4,5,7-trihydroxy-3-(3-oxobutanoyl)naphthalen-2-yl]hexanoate→tetracenomycin F2 + H2O (EC 2.3.1.235) |
| No genes |
| tetracenomycin F2→tetracenomycin F1 + H2O (EC 4.2.1.154) |
| No genes |
| tetracenomycin F1 + dioxygen→tetracenomycin D3 + H+ + H2O (EC 1.13.12.21) |
| No genes |
| tetracenomycin D3 + S-adenosyl-L-methionine→tetracenomycin B3 + S-adenosyl-L-homocysteine |
| No genes |
| tetracenomycin B3 + S-adenosyl-L-methionine→tetracenomycin E + S-adenosyl-L-homocysteine + H+ |
| RR42_RS26955 |
| tetracenomycin E + S-adenosyl-L-methionine→tetracenomycin A2 + S-adenosyl-L-homocysteine |
| No genes |
| tetracenomycin A2 + 2 NADPH + 2 dioxygen + 2 H+→tetracenomycin C + 2 NADP+ + H2O (EC 1.14.13.200) |
| No genes |
Links:
Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information